Microbiology and Clinical Microbiology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Public Health Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
J Infect Public Health. 2022 Sep;15(9):983-985. doi: 10.1016/j.jiph.2022.07.013. Epub 2022 Jul 28.
SARS-CoV-2 Omicron variant is spreading worldwide, causing unprecedented epidemic peaks due to its transmissibility and immune evasion. We searched in the archive of the Regional Microbiology Laboratory (Umbria, Italy) for immediate reinfection (i.e. infection occurring 25-60 days from primary infection) among 454,764 RT-PCR tests from 261,217 individuals. Lineage heterogeneity was assessed by S gene target failure phenomenon or whole genome sequencing. We found that BA.1 Omicron variant may cause immediate reinfection of patients just recovered from Delta infection. Immediate reinfection was not observed for any other combination of variants, including Delta over Alpha variant and BA.2 over BA.1 Omicron lineage.
SARS-CoV-2 奥密克戎变异株正在全球范围内传播，由于其传染性和免疫逃逸能力，导致前所未有的疫情高峰。我们在意大利翁布里亚地区微生物学实验室的档案中，对 261217 名个体的 454764 次 RT-PCR 检测中，搜索了即时再感染（即初次感染后 25-60 天发生的感染）。通过 S 基因靶标失败现象或全基因组测序评估谱系异质性。我们发现，BA.1 奥密克戎变异株可能导致刚从德尔塔感染中康复的患者即时再感染。任何其他变异株的组合，包括德尔塔变异株超过阿尔法变异株和 BA.2 变异株超过 BA.1 奥密克戎谱系，均未观察到即时再感染。
