Pond W G, Yen L H, Klemcke H G, Yen J T
Growth. 1986 Winter;50(4):437-46.
Two female piglets from each of 23 litters were used to determine the effect of short term maternal deprivation on liver ornithine decarboxylase (ODC) activity at 3, 10, 17, 24, and 31 days of age. Data on body weight, liver weight and plasma glucose, catecholamine and growth hormone concentrations were also recorded. Liver ODC activity declined (P less than .01) with increasing age and was reduced (P less than .0001) at each age compared with control values after maternal deprivation for 16 h. Liver weight and plasma glucose were reduced (P less than .01) by maternal deprivation, while plasma catecholamines were unchanged and plasma growth hormone tended to be reduced, although the difference between means for deprived and control animals was not significant (P greater than .05). The design of the experiment did not permit separation of the relative contributions of sensory deprivation versus food deprivation of piglets in inducing the decline in liver ODC activity. The results indicate that maternal deprivation causes a marked decrease in liver ODC activity in neonatal swine as shown previously in neonatal rats (Schanberg et al., 1984).
从23窝仔猪中各选取两只雌性仔猪，以确定短期母婴分离对3日龄、10日龄、17日龄、24日龄和31日龄仔猪肝脏鸟氨酸脱羧酶（ODC）活性的影响。同时记录仔猪体重、肝脏重量以及血浆葡萄糖、儿茶酚胺和生长激素浓度的数据。肝脏ODC活性随年龄增长而下降（P<0.01），与母婴分离16小时后的对照值相比，各年龄组的ODC活性均降低（P<0.0001）。母婴分离使肝脏重量和血浆葡萄糖降低（P<0.01），而血浆儿茶酚胺未发生变化，血浆生长激素有降低趋势，尽管母婴分离组与对照组动物均值之间的差异不显著（P>0.05）。该实验设计无法区分仔猪感觉剥夺与食物剥夺对肝脏ODC活性下降的相对影响。结果表明，母婴分离会导致新生仔猪肝脏ODC活性显著降低，这与之前在新生大鼠中的研究结果一致（Schanberg等人，1984年）。
