稳定型冠心病患者存在 tenascin-C 的预后意义。
The prognostic significance of the presence of tenascin-C in patients with stable coronary heart disease.
机构信息
Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Institute of Clinical Medicine and Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan.
出版信息
Clin Chim Acta. 2022 Oct 1;535:68-74. doi: 10.1016/j.cca.2022.08.003. Epub 2022 Aug 10.
BACKGROUND
We investigated the prognostic value of tenascin-C in patients with stable coronary heart disease.
METHODS
A total of 666 patients were enrolled and followed for 72 months. The primary outcome was a composite of cardiac events. The secondary outcomes were all-cause death, cardiovascular death, acute myocardial infarction (AMI), and heart failure hospitalization.
RESULTS
The area under the curve of tenascin-C to discriminate the occurrence of composite cardiac events was 70 % (95 % CI: 64.2 % to 75.8 %), and the corresponding optimal cutoff value was 19.91 ng/ml. A higher concentration of tenascin-C was associated with a greater risk of composite cardiac events (P trend < 0.001). Similar results were observed in all-cause death, AMI, and heart failure hospitalization.
CONCLUSION
Tenascin-C was found to be an independent predictor of total cardiovascular events in patients with stable coronary heart disease at 72 months, and also for all-cause death, AMI, and heart failure hospitalization.
背景
我们研究了 tenascin-C 在稳定性冠心病患者中的预后价值。
方法
共纳入 666 例患者，并随访 72 个月。主要终点为心脏事件的复合终点。次要终点为全因死亡、心血管死亡、急性心肌梗死（AMI）和心力衰竭住院。
结果
tenascin-C 预测复合心脏事件发生的曲线下面积为 70%（95%CI：64.2%至 75.8%），最佳截断值为 19.91ng/ml。tenascin-C 浓度越高，发生复合心脏事件的风险越大（P 趋势<0.001）。全因死亡、AMI 和心力衰竭住院也观察到类似的结果。
结论
在 72 个月时，tenascin-C 被发现是稳定性冠心病患者总心血管事件的独立预测因子，也是全因死亡、AMI 和心力衰竭住院的独立预测因子。
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