脂质过氧化作用将蛋白质转化为 DNA 模拟物。

Conversion of proteins into DNA mimetics by lipid peroxidation.

机构信息

Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan; Japan Agency for Medical Research and Development, CREST, Tokyo, Japan.

出版信息

Arch Biochem Biophys. 2022 Oct 15;728:109374. doi: 10.1016/j.abb.2022.109374. Epub 2022 Aug 11.

DOI:10.1016/j.abb.2022.109374

PMID:35964440

Abstract

Conversion of primary amino groups to pyrrole derivatives occurs by modifying lysine residues of proteins with lipid peroxidation products. Pyrrolated proteins exhibit electronegativity and electronic properties and are recognized by DNA-binding molecules, such as anti-DNA autoantibodies and DNA intercalators. This review summarizes the state of knowledge about the chemistry of this unique conversion reaction of proteins into DNA mimetics by lipid peroxidation.

摘要

一级氨基基团向吡咯衍生物的转化是通过蛋白质中赖氨酸残基与脂质过氧化产物的修饰来实现的。吡咯化蛋白质表现出电负性和电子特性，并被 DNA 结合分子识别，如抗 DNA 自身抗体和 DNA 嵌入剂。这篇综述总结了有关脂质过氧化将蛋白质转化为 DNA 类似物的这一独特转化反应的化学知识的现状。