通过 1,4-双（苯乙炔基）苯片段将 C-19 连接的荧光甾体二聚体的合成与表征。
Synthesis and characterization of a fluorescent steroid dimer linked through C-19 by a 1,4-Bis(phenylethynyl)phenylene fragment.
机构信息
Facultad de Química, Universidad Nacional Autónoma de México. CDMX, 04510, México.
Facultad de Química, Universidad Nacional Autónoma de México. CDMX, 04510, México.
出版信息
Steroids. 2022 Nov;187:109098. doi: 10.1016/j.steroids.2022.109098. Epub 2022 Aug 12.
The synthesis and characterization of a dimer in which two nuclei of 3β-acetoxy-19-hydroxyandrost-5-en-17-one are linked by the fluorescent 1,4-bis(phenylethynyl)phenylene bridge attached to the oxygenated functions at positions C-19 of each steroid fragment is described. The compound was obtained in five steps and 23 % overall yield and showed a strong blue emission with a quantum yield of 0.66.
描述了一种二聚体的合成和表征，其中两个 3β-乙酰氧基-19-羟基雄甾-5-烯-17-酮的核通过连接在每个甾体片段 C-19 上的含氧官能团的荧光 1,4-双（苯乙炔基）苯桥连接。该化合物通过五步反应以 23%的总产率得到，并表现出强烈的蓝色发射，量子产率为 0.66。
Zotero 插件