Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; CIBEREHD, Pamplona, Spain.
Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Int Rev Cell Mol Biol. 2022;371:1-14. doi: 10.1016/bs.ircmb.2022.04.012. Epub 2022 Jun 21.
Dendritic cells (DCs) are professional antigen presenting cells that play an important role in the induction of T cell responses. Different subsets (cDC1s, cDC2s, pDCs, and moDCs) were described based on the expression of different surface markers and functions. In the context of peritoneum, DCs are also a key population cell orchestrating immune responses against pathogens, malignant cells and tissue-damage. Furthermore, they play an important role in the promotion of an anti-inflammatory microenvironment, which is necessary to maintain tolerance and adipocyte homeostasis. The aim of this review is to summarize the current knowledge of the functional and phenotypic features of peritoneal DCs and shed some light on the importance of these cells within this unique cavity and its associated components: the omentum, the mesentery and gut-associated lymphoid tissue (GALT).
树突状细胞（DCs）是专业的抗原呈递细胞，在诱导 T 细胞反应中发挥重要作用。不同的亚群（cDC1s、cDC2s、pDCs 和 moDCs）根据不同的表面标志物和功能进行描述。在腹膜环境中，DCs 也是协调针对病原体、恶性细胞和组织损伤的免疫反应的关键细胞群。此外，它们在促进抗炎微环境中发挥重要作用，这对于维持耐受和脂肪细胞稳态是必要的。本综述的目的是总结目前对腹膜 DCs 的功能和表型特征的认识，并阐明这些细胞在这个独特腔及其相关成分（网膜、肠系膜和肠道相关淋巴组织（GALT））中的重要性。
