Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Trends Mol Med. 2022 Oct;28(10):850-863. doi: 10.1016/j.molmed.2022.07.003. Epub 2022 Aug 12.
Neuroinflammatory diseases remain a therapeutic challenge, notably when progressing towards neurodegeneration. In this context, multiple sclerosis represents a central nervous system (CNS) disorder that combines pathogenic inflammatory and degenerative processes. Immunosuppression is effective for managing inflammatory activity, but neurodegenerative processes secondary to chronic inflammation are often refractory to contemporary treatments. Recent evidence indicates that pathways involved in chronic neuroinflammation demonstrate features of cellular senescence. These features could provide a framework that could serve as a target for senotherapeutics. In this review, we discuss the unmet need for strategies capable of overcoming the treatment resistance of neuroinflammatory diseases, and we discuss the potential of cellular senescence towards developing these strategies.
神经炎症性疾病仍然是一个治疗挑战，尤其是在向神经退行性病变发展时。在这种情况下，多发性硬化症代表了一种中枢神经系统（CNS）疾病，其结合了致病性炎症和退行性过程。免疫抑制对控制炎症活动有效，但慢性炎症引起的神经退行性过程往往对现代治疗方法有抗性。最近的证据表明，慢性神经炎症相关的途径具有细胞衰老的特征。这些特征可以提供一个框架，作为治疗衰老的靶点。在这篇综述中，我们讨论了克服神经炎症性疾病治疗抗性的策略的未满足需求，并讨论了细胞衰老在开发这些策略方面的潜力。
