Faghani Maryam, Jenabian Niloofar, Haghanifar Sina, Khafri Sorayya
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Health Research Center, Health Research Institute. Babol University of Medical Sciences, Babol, Iran.
Front Dent. 2021 Jul 20;18:23. doi: 10.18502/fid.v18i23.6933. eCollection 2021.
Intrabony defects are among the most important signs of progression of periodontal disease. Complete tissue regeneration is the ideal goal of periodontal treatment, and regenerative methods aim to achieve this goal. New studies have reported the positive efficacy of chitosan to enhance the recovery of bony defects. This study aimed to clinically and radiographically assess the efficacy of chitosan particles for treatment of intrabony periodontal defects. In this clinical trial, 18 intrabony three-wall periodontal defects were randomly divided into three groups (n=6). The control group only received conventional flap surgery with a sulcular incision. In the second group, low molecular weight (100,000-300,000g/mol) chitosan was used in the three-wall intrabony defects during surgery while high molecular weight chitosan particles (600,000-800,000 g/mol) were used in the third group. The probing pocket depth (PPD), clinical attachment level (CAL) and radiographic defect depth (RDD) were measured at baseline and at 6 and 12 months later. Repeated measures ANOVA, and McNemar's test were used for statistical analysis. In both the control (P<0.001) and coarse chitosan (P=0.035) groups, a significant difference was noted in PPD before and after surgery. CAL was not significantly different among the three groups (P>0.05). No significant difference was noted on radiographs between the groups regarding the regenerated bone density. Chitosan showed no positive efficacy for treatment of three-wall periodontal bone defects.
骨内缺损是牙周病进展的最重要体征之一。组织完全再生是牙周治疗的理想目标，而再生方法旨在实现这一目标。新的研究报道了壳聚糖在促进骨缺损恢复方面的积极疗效。本研究旨在通过临床和影像学评估壳聚糖颗粒治疗骨内牙周缺损的疗效。在这项临床试验中，18个骨内三壁牙周缺损被随机分为三组（n = 6）。对照组仅接受带沟内切口的传统翻瓣手术。第二组在手术过程中，在三壁骨内缺损处使用低分子量（100,000 - 300,000 g/mol）壳聚糖，而第三组使用高分子量壳聚糖颗粒（600,000 - 800,000 g/mol）。在基线以及术后6个月和12个月测量探诊深度（PPD）、临床附着水平（CAL）和影像学缺损深度（RDD）。采用重复测量方差分析和McNemar检验进行统计分析。在对照组（P < 0.001）和粗壳聚糖组（P = 0.035）中，手术前后PPD均有显著差异。三组之间CAL无显著差异（P > 0.05）。在影像学上，各组之间再生骨密度无显著差异。壳聚糖对治疗三壁牙周骨缺损未显示出积极疗效。
