Christgau M, Moder D, Wagner J, Glässl M, Hiller K-A, Wenzel A, Schmalz G
Department of Operative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany.
J Clin Periodontol. 2006 Dec;33(12):908-21. doi: 10.1111/j.1600-051X.2006.00999.x.
To investigate the influence of autologous platelet concentrate (APC) on early wound healing and regeneration outcomes following guided tissue regeneration (GTR) therapy.
In 25 patients, two contralateral deep intra-bony defects were treated with beta-TCP and a bioresorbable GTR membrane. They were randomly assigned to test and control procedure. In test defects, APC was additionally applied. After 3, 6, and 12 months, healing results were assessed by clinical parameters and quantitative digital subtraction radiography.
Post-operative membrane exposures occurred in 48% of the test sites and 80% of the control sites. Both groups revealed a significant clinical attachment level (CAL) gain of 5 mm after 12 months. Eighty-eight per cent of test and control sites showed a CAL gain of > or =4 mm. No clinical parameter revealed significant differences between test and control sites. A significant bone density gain was found in both groups after 3, 6, and 12 months. Only after 6 months, the bone density gain was significantly greater in the test defects.
Within the limits of this study, autologous platelet concentrate did not seem to have a noticeable influence on the clinical and most of the radiographic outcomes following GTR. However, APC might reduce the occurrence of post-operative membrane exposures and accelerate bone density gain.
探讨自体血小板浓缩液（APC）对引导组织再生（GTR）治疗后早期伤口愈合和再生效果的影响。
对25例患者的双侧深部骨内缺损采用β-磷酸三钙和可生物吸收的GTR膜进行治疗。将患者随机分为试验组和对照组。试验组缺损部位额外应用APC。在术后3个月、6个月和12个月时，通过临床参数和定量数字减影放射成像评估愈合结果。
试验组48%的位点和对照组80%的位点出现术后膜暴露。两组在12个月后均显示临床附着水平（CAL）显著增加5 mm。试验组和对照组88%的位点CAL增加≥4 mm。试验组和对照组之间的临床参数均未显示出显著差异。两组在术后3个月、6个月和12个月时均发现骨密度显著增加。仅在6个月后，试验组缺损部位的骨密度增加更为显著。
在本研究范围内，自体血小板浓缩液似乎对GTR治疗后的临床和大多数影像学结果没有明显影响。然而，APC可能会减少术后膜暴露的发生并加速骨密度增加。
