Chen Fang, Zhang Qiong, Tian Xin, Chen Min, Dong Yudi, Wu Qiaoyuan, Chen Yuling, Luo Qin
Department of Oncology Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Transl Cancer Res. 2022 Jul;11(7):2408-2415. doi: 10.21037/tcr-22-1166.
Among the malignant tumors that occur in the nasopharynx, nasopharyngeal carcinoma is the most common. Nasopharyngeal carcinoma (NPC) is commonly diagnosed in Southeastern Asia, particularly in southern China. It originates from the epithelial lining of the nasopharynx and has a variety of pathological subtypes. The vast majority of NPC cases are keratinizing or nonkeratinizing squamous cell carcinoma. Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is an extremely rare malignant tumor. Most reports regarding this disease mainly focus on clinical diagnosis and pathology; however, reports regarding therapy and follow-up are relatively limited. The case in the study presents a female patient with LGNPPA. The patient underwent endoscopic resection and adjuvant radiotherapy. Following-up 6 years, the patient was free of local recurrence and distant metastasis. Because of the very low incidence, there are no guidelines or protocols developed for proper, standardized therapy, we aim to provide useful recommendations regarding optimal treatment strategies by exploring the therapeutic expectancies of the rare disease.
A 45-year-old female of Han ethnicity visited a local hospital for over 2 years of recurrent nasal congestion. The patient had no previous medical history, had a history of smoking (6 years, 20 cigarettes per day) and drank occasionally. but had no family history of cancer. Epstein-Barr virus (EBV) DNA was <500×10 IU/mL. Based on findings from computed tomography (CT) scans of the nasal cavity and paranasal sinuses, nasal endoscopy, and postoperative pathology, the diagnosis was low-grade papillary adenocarcinoma located at the upper nasopharynx (T1N0M0, stage I). This patient underwent endoscopic resection. After the endoscopic resection, she received intensity-modulated radiotherapy. After radiotherapy, there was no residual by nasopharyngo-fiberoscope. And she was free of local recurrence and distant metastasis at 6 years of follow-up.
Although primary nasopharyngeal adenocarcinomas (NPACs) are very rare, they also should be pay attention to. As far as treatment policy, no standard treatment exists for the tumors. So through this case report, we want to provide a possible useful recommendations regarding optimal treatment strategies by exploring the therapeutic expectations of this rare disease.
在发生于鼻咽部的恶性肿瘤中，鼻咽癌最为常见。鼻咽癌（NPC）在东南亚地区，尤其是中国南方地区较为常见。它起源于鼻咽部的上皮组织，有多种病理亚型。绝大多数鼻咽癌病例为角化或非角化鳞状细胞癌。低级别鼻咽乳头状腺癌（LGNPPA）是一种极其罕见的恶性肿瘤。关于这种疾病的大多数报告主要集中在临床诊断和病理学方面；然而，关于治疗和随访的报告相对有限。本研究中的病例为一名患有LGNPPA的女性患者。该患者接受了内镜下切除及辅助放疗。随访6年，患者无局部复发及远处转移。由于发病率极低，目前尚无针对恰当、标准化治疗制定的指南或方案，我们旨在通过探索这种罕见疾病的治疗预期，提供有关最佳治疗策略的有用建议。
一名45岁汉族女性因反复鼻塞2年余就诊于当地医院。患者既往无病史，有吸烟史（6年，每天20支），偶尔饮酒，但无癌症家族史。爱泼斯坦-巴尔病毒（EBV）DNA＜500×10 IU/mL。根据鼻腔及鼻窦计算机断层扫描（CT）、鼻内镜检查及术后病理结果，诊断为位于鼻咽上部的低级别乳头状腺癌（T1N0M0，Ⅰ期）。该患者接受了内镜下切除。内镜切除术后，她接受了调强放疗。放疗后，鼻咽纤维镜检查未见残留。随访6年，她无局部复发及远处转移。
尽管原发性鼻咽腺癌（NPACs）非常罕见，但也应予以关注。就治疗策略而言，目前尚无针对此类肿瘤的标准治疗方法。因此，通过本病例报告，我们希望通过探索这种罕见疾病的治疗预期，提供有关最佳治疗策略的可能有用的建议。
