Maocai Li, Fuxing Liu, Lianqing Li, Lili Gong, WenChao Duan, ShouZhou Liu
Department of Otolaryngology, Head and Neck Surgery, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Medicine (Baltimore). 2020 Aug 14;99(33):e21599. doi: 10.1097/MD.0000000000021599.
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and the abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical and morphological characteristics and the treatment provided.
The patient was a 50-year-old Chinese woman with the complaint of a three-year history of phlegm with blood with pharyngeal discomfort. There were no remarkable physical findings, and the laboratory tests were normal. Laryngoscopy and nasal computed tomography identified a mass at the posterior end of the nasal septum. Histologically, the tumor exhibited an oval papillary growth. Immunohistochemically, the neoplastic cells were positive for TTF-1, vimentin, cytokeratin 7, and cytokeratin 19. Pathological examination indicated a thyroid-like low-grade nasopharyngeal papillary adenocarcinoma.
The neoplasm was completely resected without any complication.
The patient had neither local recurrence nor distant metastasis 1 year after the removal of the tumor.
Although TL-LGNPPA is a malignant tumor, complete surgical resection is an effective treatment.
甲状腺样低级别鼻咽乳头状腺癌（TL-LGNPPA）是一种罕见的肿瘤，其特征是在形态上类似于甲状腺乳头状癌，并伴有甲状腺转录因子-1（TTF-1）的异常表达。我们在此报告一例罕见的TL-LGNPPA病例，并对其临床和形态学特征以及所提供的治疗进行综述。
该患者为一名50岁的中国女性，主诉有三年咳痰带血伴咽部不适的病史。体格检查无明显异常，实验室检查正常。喉镜检查和鼻窦计算机断层扫描发现鼻中隔后端有一个肿块。组织学检查显示肿瘤呈椭圆形乳头状生长。免疫组织化学检查显示，肿瘤细胞TTF-1、波形蛋白、细胞角蛋白7和细胞角蛋白19呈阳性。病理检查提示为甲状腺样低级别鼻咽乳头状腺癌。
肿瘤被完整切除，无任何并发症。
肿瘤切除1年后，患者既无局部复发也无远处转移。
尽管TL-LGNPPA是一种恶性肿瘤，但完整的手术切除是一种有效的治疗方法。
