Bellini Rossella, Bonacina Fabrizia, Norata Giuseppe Danilo
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Center for the Study of Atherosclerosis, E. Bassini Hospital, Cinisello Balsamo, Milan, Italy.
Front Cardiovasc Med. 2022 Jul 28;9:934314. doi: 10.3389/fcvm.2022.934314. eCollection 2022.
Atherosclerosis is a chronic disease resulting from an impaired lipid and immune homeostasis, where the interaction between innate and adaptive immune cells leads to the promotion of atherosclerosis-associated immune-inflammatory response. Emerging evidence has suggested that this response presents similarities to the reactivity of effector immune cells toward self-epitopes, often as a consequence of a . In this context, dendritic cells, a heterogeneous population of antigen presenting cells, play a key role in instructing effector T cells to react against foreign antigens and T regulatory cells to maintain tolerance against self-antigens and/or to patrol for self-reactive effector T cells. Alterations in this delicate balance appears to contribute to atherogenesis. The aim of this review is to discuss different DC subsets, and their role in atherosclerosis as well as in T cell polarization. Moreover, we will discuss how loss of T cell tolerogenic phenotype participates to the immune-inflammatory response associated to atherosclerosis and how a better understanding of these mechanisms might result in designing immunomodulatory therapies targeting DC-T cell crosstalk for the treatment of atherosclerosis-related inflammation.
动脉粥样硬化是一种因脂质和免疫稳态受损而引发的慢性疾病，在这种疾病中，固有免疫细胞和适应性免疫细胞之间的相互作用会促进与动脉粥样硬化相关的免疫炎症反应。新出现的证据表明，这种反应与效应免疫细胞对自身表位的反应性存在相似之处，这通常是由于……的结果。在这种情况下，树突状细胞作为一种异质性的抗原呈递细胞群体，在指导效应T细胞对外来抗原作出反应以及调节性T细胞维持对自身抗原的耐受性和/或巡查自身反应性效应T细胞方面发挥着关键作用。这种微妙平衡的改变似乎会促进动脉粥样硬化的发生。本综述的目的是讨论不同的树突状细胞亚群及其在动脉粥样硬化以及T细胞极化中的作用。此外，我们将讨论T细胞耐受性表型的丧失如何参与与动脉粥样硬化相关的免疫炎症反应，以及对这些机制的更好理解如何可能导致设计针对树突状细胞 - T细胞相互作用的免疫调节疗法来治疗动脉粥样硬化相关炎症。
