Ahuja Manik, Awasthi Manul, Gim Suzanna, Records Kathie, Cimilluca Johanna, Al-Ksir Kawther, Tremblay Johnathan, Doshi Riddhi P, Sathiyasaleen Thiveya, Fernandopulle Praveen
College of Public Health, East Tennessee State University, Johnson City, TN, USA.
LUI Pharmacy, Long Island University, Brooklyn, NY, USA.
Subst Abuse. 2022 Aug 10;16:11782218221116731. doi: 10.1177/11782218221116731. eCollection 2022.
Suicide rates in the U.S. have continued to rise over the last 2 decades. The increased availability and broader legalization of cannabis is a public health concern, particularly among adolescents. The objective of this study was to examine the association between the age of cannabis initiation and lifetime suicidal ideations and attempts in a sample of adults aged 18 or older.
Data are from the Collaborative Psychiatric Epidemiology Surveys (CPES), 2001 to 2003 (N = 15 238). The primary objective of the CPES was to collect data about the prevalence of mental disorders, impairments associated with these disorders, and their treatment patterns from representative samples of majority and minority adult populations in the U.S. Logistic regression analyses were conducted to test the association between cannabis initiation age (early ⩽14 years old; later >14 years old) and outcomes of lifetime suicide ideation and attempts. Cigarette use, cannabis use, gender, income, race, education, and age were controlled for the analyses.
Overall, 12.5% of participants reported suicide ideation, while 4.2% reported attempt. Early cannabis use was associated with a higher risk of suicide ideation (AOR = 3.32, 95% CI [2.75, 3.80]) than later cannabis use (AOR = 2.15, 95% CI [1.92, 2.39]). Early cannabis use was associated with a higher risk of suicide attempt (AOR = 4.38, 95% CI [3.48, 5.52]) than later cannabis use (AOR = 2.56, 95% CI [2.14, 3.06]). Wald chi-squared tests revealed significant differences between the early and late initiation for both ideation (χ = 26.99; < .001) and attempts (χ = 26.02; < .001).
Significant associations were found between early initiation of cannabis and suicide behaviors. As suicide rates continue to rise, it is recommended that clinicians, treatment providers, and other professionals consider the use of cannabis at an early age as a risk for subsequent suicide behaviors.
在过去20年里,美国的自杀率持续上升。大麻的可获得性增加及其更广泛的合法化引发了公共卫生担忧,尤其是在青少年中。本研究的目的是在18岁及以上的成年人样本中,研究开始使用大麻的年龄与终生自杀意念和自杀未遂之间的关联。
数据来自2001年至2003年的协作精神疾病流行病学调查(CPES)(N = 15238)。CPES的主要目的是从美国多数和少数成年人群的代表性样本中收集有关精神障碍患病率、与这些障碍相关的损害及其治疗模式的数据。进行逻辑回归分析以检验开始使用大麻的年龄(早期≤14岁;晚期>14岁)与终生自杀意念和自杀未遂结果之间的关联。分析中对吸烟、大麻使用、性别、收入、种族、教育程度和年龄进行了控制。
总体而言,12.5%的参与者报告有自杀意念,而4.2%的参与者报告有自杀未遂。与晚期开始使用大麻(比值比[AOR]=2.15,95%置信区间[CI][1.92, 2.39])相比,早期使用大麻与更高的自杀意念风险相关(AOR = 3.32,95% CI [2.75, 3.80])。与晚期开始使用大麻(AOR = 2.56,95% CI [2.14, 3.06])相比,早期使用大麻与更高的自杀未遂风险相关(AOR = 4.38,95% CI [3.48, 5.52])。Wald卡方检验显示,在自杀意念(χ = 26.99;P <.001)和自杀未遂(χ = 26.02;P <.001)方面,早期和晚期开始使用大麻之间存在显著差异。
发现早期开始使用大麻与自杀行为之间存在显著关联。由于自杀率持续上升,建议临床医生、治疗提供者和其他专业人员将早年使用大麻视为后续自杀行为的一个风险因素。