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加味痛泻要方对腹泻型肠易激综合征肠道微生态的影响及机制

Effect and Mechanism of Flavored Tongxie Yaofang Decoction for Diarrheal Irritable Bowel Syndrome under Intestinal Microecology.

作者信息

He Shunyong, Lin Qiong, Huang Jianfeng, Zheng Lin, Lai Jinmei, Chen Chaoyuan

机构信息

The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian, China.

出版信息

Evid Based Complement Alternat Med. 2022 Aug 3;2022:3904571. doi: 10.1155/2022/3904571. eCollection 2022.

Abstract

This research was to analyze the effect of flavored Tongxie Yaofang on diarrheal irritable bowel syndrome (IBS) by the situation of intestinal microecology. The treatment mechanism was analyzed, so as to provide a more effective treatment method for patients clinically. 60 IBS patients were selected as the research objects and were divided according to the different treatment methods. For the control group ( = 20 cases), oral pinaverium bromide tablets were given. For the treatment group ( = 40 cases), the flavored Tongxie Yaofang decoction was given in addition to conventional treatment. The curative effects on the two groups of patients were evaluated in combination with the changes in intestinal microecology. With the syndrome score, the total effective rate of the treatment group (92.5%) was obviously superior to the control group (80%) ( < 0.05). The clinical symptoms such as abdominal pain, abdominal distension, and diarrhea in the treatment group were significantly relieved after treatment in contrast to the control group ( < 0.05). Intestinal Bifidobacterium, , and Bifidobacterium/ (B/) ratio were all greatly higher than those in the control group ( < 0.05). In summary, flavored Tongxie Yaofang had a good effect in improving the symptoms of patients with diarrheal IBS and improved the microflora of Bifidobacterium and in the intestinal tract of patients.

摘要

本研究旨在通过肠道微生态状况分析加味痛泻要方对腹泻型肠易激综合征(IBS)的影响。分析其治疗机制,以便为临床患者提供更有效的治疗方法。选取60例IBS患者作为研究对象,根据不同治疗方法进行分组。对照组(=20例)口服匹维溴铵片。治疗组(=40例)在常规治疗基础上加用加味痛泻要方汤剂。结合肠道微生态变化对两组患者的疗效进行评估。从证候积分来看,治疗组总有效率(92.5%)明显优于对照组(80%)(<0.05)。与对照组相比,治疗组治疗后腹痛、腹胀、腹泻等临床症状明显缓解(<0.05)。肠道双歧杆菌、和双歧杆菌/(B/)比值均显著高于对照组(<0.05)。综上所述,加味痛泻要方在改善腹泻型IBS患者症状方面效果良好,且改善了患者肠道双歧杆菌和的微生态菌群。

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