Nouchi Rui, Hu Qingqiang, Ushida Yusuke, Suganuma Hiroyuki, Kawashima Ryuta
Department of Cognitive Health Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Smart Aging Research Center, Tohoku University, Sendai, Japan.
Front Aging Neurosci. 2022 Jul 29;14:929628. doi: 10.3389/fnagi.2022.929628. eCollection 2022.
Recent studies have reported that sulforaphane (SFN) intake with cognitive training had positive effects on cognitive functions. However, it is still unknown whether SFN intake alone has beneficial effects on cognition as well as mood. We investigated whether a SFN intake intervention improved cognitive performance and mood states in healthy older adults.
In a 12-week, double-blinded, randomized controlled trial (RCT), we randomly assigned 144 older adults to a SFN group or a placebo group. We asked the participants to take a supplement (SFN or placebo) for 12 weeks. We measured several cognitive functions, mood states, and biomarkers before and after the intervention period.
The SFN group showed improvement in processing speed and a decrease in negative mood compared to the placebo group. In addition, the SFN group exhibited a higher SFN--acetyl-L-cysteine (NAC) level compared to the placebo group. However, there were no significant results in other biomarkers of oxidant stress, inflammation, or neural plasticity.
These results indicate that nutrition interventions using SFN can have positive effects on cognitive functioning and mood in healthy older adults.
近期研究报告称，摄入萝卜硫素（SFN）并结合认知训练对认知功能有积极影响。然而，单独摄入SFN是否对认知以及情绪有益仍不明确。我们调查了SFN摄入干预是否能改善健康老年人的认知表现和情绪状态。
在一项为期12周的双盲随机对照试验（RCT）中，我们将144名老年人随机分为SFN组或安慰剂组。我们要求参与者服用补充剂（SFN或安慰剂）12周。在干预期前后，我们测量了多项认知功能、情绪状态和生物标志物。
与安慰剂组相比，SFN组在处理速度上有所改善，负面情绪有所减少。此外，与安慰剂组相比，SFN组的SFN-乙酰半胱氨酸（NAC）水平更高。然而，在氧化应激、炎症或神经可塑性的其他生物标志物方面没有显著结果。
这些结果表明，使用SFN的营养干预对健康老年人的认知功能和情绪有积极影响。
