• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿扎胞苷诱发的急性髓系白血病合并白细胞增多症患者的肺炎

Azacitidine-Induced Pneumonitis in a Patient With Acute Myeloid Leukemia and Hyperleukocytosis.

作者信息

Litvin Rafaella, Dasgupta Mona, Saad Eldin Mohamed, Shah Mihir, Fakhran Sherene

机构信息

Department of Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Department of Pulmonary, Critical Care and Sleep Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

出版信息

Cureus. 2022 Jul 11;14(7):e26758. doi: 10.7759/cureus.26758. eCollection 2022 Jul.

DOI:10.7759/cureus.26758
PMID:35967130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9365400/
Abstract

Chemotherapy-related toxicity is a complex aspect of oncologic care. Pulmonary toxicity, in particular, poses a significant challenge, as it can have diverse presentations and can closely mimic other common complications of cancer treatment, such as infections. Azacitidine is an agent widely employed in high-risk myelodysplastic syndrome and acute myeloid leukemia. We present a case of azacitidine-induced pneumonitis, a rare adverse effect, in a 70-year-old patient with acute myeloid leukemia (AML) and hyperleukocytosis. After discontinuation of the drug and introduction of steroids, the patient had complete resolution of symptoms, highlighting the importance of identifying and addressing chemotherapy-induced pneumonitis.

摘要

化疗相关毒性是肿瘤护理中的一个复杂方面。尤其是肺部毒性构成了重大挑战，因为它可能有多种表现形式，并且可能与癌症治疗的其他常见并发症（如感染）极为相似。阿扎胞苷是一种广泛用于高危骨髓增生异常综合征和急性髓系白血病的药物。我们报告一例70岁急性髓系白血病（AML）合并白细胞增多症患者发生阿扎胞苷诱发的肺炎，这是一种罕见的不良反应。在停药并使用类固醇后，患者症状完全缓解，凸显了识别和处理化疗诱发肺炎的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/9e933567f4f2/cureus-0014-00000026758-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/cd2bfa662df8/cureus-0014-00000026758-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/31a16e543747/cureus-0014-00000026758-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/586c6a67c7a8/cureus-0014-00000026758-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/9e933567f4f2/cureus-0014-00000026758-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/cd2bfa662df8/cureus-0014-00000026758-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/31a16e543747/cureus-0014-00000026758-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/586c6a67c7a8/cureus-0014-00000026758-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb6/9365400/9e933567f4f2/cureus-0014-00000026758-i04.jpg

相似文献

1
Azacitidine-Induced Pneumonitis in a Patient With Acute Myeloid Leukemia and Hyperleukocytosis.阿扎胞苷诱发的急性髓系白血病合并白细胞增多症患者的肺炎
Cureus. 2022 Jul 11;14(7):e26758. doi: 10.7759/cureus.26758. eCollection 2022 Jul.
2
Azacitidine-Induced Interstitial Pneumonitis.阿扎胞苷诱导的间质性肺炎。
Am J Ther. 2016 Sep-Oct;23(5):e1205-8. doi: 10.1097/MJT.0000000000000300.
3
Azacitidine or intensive chemotherapy for older patients with secondary or therapy-related acute myeloid leukemia.阿扎胞苷或强化化疗用于老年继发性或治疗相关急性髓系白血病患者。
Oncotarget. 2017 Mar 7;8(45):79126-79136. doi: 10.18632/oncotarget.15988. eCollection 2017 Oct 3.
4
Azacitidine as salvage therapy for acute myeloid leukemia in a severely ill patient.阿扎胞苷作为一名重症患者急性髓系白血病挽救治疗的应用
Hematol Rep. 2014 Sep 30;6(3):5516. doi: 10.4081/hr.2014.5516. eCollection 2014 Aug 26.
5
Azacitidine induced lung injury: report and contemporary discussion on diagnosis and management.阿扎胞苷所致肺损伤：病例报告及关于诊断与管理的当代讨论
Front Oncol. 2024 Feb 9;14:1345492. doi: 10.3389/fonc.2024.1345492. eCollection 2024.
6
Real Life Data on Efficacy and Safety of Azacitidine Therapy for Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia.真实世界中阿扎胞苷治疗骨髓增生异常综合征、慢性粒单核细胞白血病和急性髓系白血病的疗效和安全性数据。
Pathol Oncol Res. 2019 Jul;25(3):1175-1180. doi: 10.1007/s12253-018-00574-0. Epub 2019 Jan 6.
7
A systematic review and metaanalysis of the efficacy and adverse events of azacitidinepluslenalidomide treatment for patients with acute myeloid leukemia, myelodysplastic syndromes and chronic myelomonocytic leukemia .阿扎胞苷联合来那度胺治疗急性髓系白血病、骨髓增生异常综合征和慢性粒单核细胞白血病的疗效及不良事件的系统评价和荟萃分析
Hematology. 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425.
8
A phase 1b/2 study of azacitidine with PD-L1 antibody avelumab in relapsed/refractory acute myeloid leukemia.一项评估阿扎胞苷联合 PD-L1 抗体avelumab 治疗复发/难治性急性髓系白血病的 1b/2 期研究。
Cancer. 2021 Oct 15;127(20):3761-3771. doi: 10.1002/cncr.33690. Epub 2021 Jun 25.
9
Pevonedistat in East Asian patients with acute myeloid leukemia or myelodysplastic syndromes: a phase 1/1b study to evaluate safety, pharmacokinetics and activity as a single agent and in combination with azacitidine.在东亚患有急性髓系白血病或骨髓增生异常综合征的患者中：一项评估单药及联合阿扎胞苷的安全性、药代动力学和疗效的 1/1b 期研究。
J Hematol Oncol. 2022 May 11;15(1):56. doi: 10.1186/s13045-022-01264-w.
10
Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the Study Alliance Leukemia.阿扎胞苷联合强化诱导化疗治疗老年急性髓系白血病：白血病研究联盟 AML-AZA 试验。
Leukemia. 2016 Mar;30(3):555-61. doi: 10.1038/leu.2015.306. Epub 2015 Nov 2.

引用本文的文献

1
Multi-Organ Adverse Reaction to Two Hypomethylating Agents: A Challenge in High-Risk Myelodysplastic Syndrome Treatment.两种去甲基化药物引起的多器官不良反应：高危骨髓增生异常综合征治疗中的一项挑战
Hematol Rep. 2025 May 30;17(3):29. doi: 10.3390/hematolrep17030029.
2
Azacitidine induced lung injury: report and contemporary discussion on diagnosis and management.阿扎胞苷所致肺损伤：病例报告及关于诊断与管理的当代讨论
Front Oncol. 2024 Feb 9;14:1345492. doi: 10.3389/fonc.2024.1345492. eCollection 2024.
3
Approach to the Older Patient with Acute Myeloid Leukemia.

本文引用的文献

1
British Society for Haematology guidelines for the management of adult myelodysplastic syndromes.英国血液学学会成人骨髓增生异常综合征管理指南
Br J Haematol. 2021 Jul;194(2):267-281. doi: 10.1111/bjh.17612. Epub 2021 Jun 27.
2
Azacitidine-induced pneumonitis and literature review.阿扎胞苷所致肺炎及文献复习。
BMJ Case Rep. 2020 Oct 29;13(10):e236349. doi: 10.1136/bcr-2020-236349.
3
American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults.美国血液学会2020年老年初诊急性髓系白血病治疗指南。
老年急性髓系白血病患者的处理方法。
Curr Oncol Rep. 2023 Nov;25(11):1203-1211. doi: 10.1007/s11912-023-01450-0. Epub 2023 Sep 9.
Blood Adv. 2020 Aug 11;4(15):3528-3549. doi: 10.1182/bloodadvances.2020001920.
4
Autopsy findings in patients with acute myeloid leukemia and non-Hodgkin lymphoma in the modern era: a focus on lung pathology and acute respiratory failure.现代时代急性髓系白血病和非霍奇金淋巴瘤患者的尸检结果：重点关注肺部病理学和急性呼吸衰竭。
Ann Hematol. 2019 Jan;98(1):119-129. doi: 10.1007/s00277-018-3494-3. Epub 2018 Sep 14.
5
Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome.阿扎胞苷诱发的治疗相关性骨髓增生异常综合征患者急性肺损伤
J Int Med Res. 2017 Apr;45(2):886-893. doi: 10.1177/0300060517698331. Epub 2017 Mar 16.
6
Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia.骨髓增生异常综合征和急性髓系白血病患者阿扎核苷治疗的肺部并发症
Case Rep Hematol. 2015;2015:357461. doi: 10.1155/2015/357461. Epub 2015 Dec 20.
7
Azacitidine-induced cryptogenic organizing pneumonia: a case report and review of the literature.阿扎胞苷诱发的隐源性机化性肺炎：一例病例报告及文献复习
J Med Case Rep. 2016 Jan 20;10:15. doi: 10.1186/s13256-016-0803-0.
8
Hypomethylating therapy and autoimmunity in MDS: an enigmatic relationship.骨髓增生异常综合征中的低甲基化治疗与自身免疫：一种神秘的关系。
Leuk Res. 2012 Apr;36(4):e90-2. doi: 10.1016/j.leukres.2011.12.013. Epub 2012 Jan 9.
9
Interstitial lung disease associated with azacitidine use: a case report.阿扎胞苷治疗相关的间质性肺疾病：一例报告。
Am J Ther. 2012 Mar;19(2):e98-e100. doi: 10.1097/MJT.0b013e3181e7a526.
10
Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome.
Pharmacotherapy. 2007 Dec;27(12):1759-62. doi: 10.1592/phco.27.12.1759.