Trenti T, Ventura E, Ceccarelli D, Masini A
IARC Sci Publ. 1986(77):457-9.
This study investigated the extent of impairment in functional parameters of liver mitochondria from rats treated for 60 days with hexachlorobenzene (HCB). A constant amount of mitochondrial uncoupling was found throughout the treatment period. At the same time a nearly constant amount of pentachlorophenol was detected in these mitochondria. In contrast, the level of mitochondrial porphyrins increased progressively. There was good correlation between the concentration of mitochondrial pentachlorophenol and the degree of uncoupling of oxidative phosphorylation.
本研究调查了用六氯苯（HCB）处理60天的大鼠肝脏线粒体功能参数的受损程度。在整个治疗期间发现线粒体解偶联量恒定。同时，在这些线粒体中检测到几乎恒定的五氯苯酚量。相比之下，线粒体卟啉水平逐渐升高。线粒体五氯苯酚浓度与氧化磷酸化解偶联程度之间存在良好的相关性。
