Trenti T, Ventura E, Ceccarelli D, Masini A
IARC Sci Publ. 1986(77):329-31.
This study investigated impairment of oxidative phosphorylation in mitochondria isolated from the liver of hexachlorobenzene (HCB)-treated rats. Partial and reversible uncoupling of the phosphorylative process was found in liver mitochondria from rats dosed with HCB for 60 days. Pentachlorophenol, endogenously formed by HCB metabolism, was detected in the mitochondria at a concentration of 0.3-0.4 nmol/mg protein. Based on the effect of pentachlorophenol, added in vitro at a concentration similar to that found in vivo, it was concluded that the uncoupling of oxidative phosphorylation under these experimental conditions was almost completely due to the presence of pentachlorophenol.
本研究调查了从六氯苯（HCB）处理的大鼠肝脏中分离出的线粒体氧化磷酸化的损伤情况。在给予HCB 60天的大鼠肝脏线粒体中发现了磷酸化过程的部分且可逆的解偶联现象。在线粒体中检测到由HCB代谢内源性形成的五氯苯酚，其浓度为0.3 - 0.4 nmol/mg蛋白质。基于体外添加浓度与体内发现浓度相似的五氯苯酚的作用，得出在这些实验条件下氧化磷酸化解偶联几乎完全是由于五氯苯酚的存在。
