Siegel-Scott C, Johnson A E
IARC Sci Publ. 1986(77):629-34.
Hexachlorobenzene (HCB) has been shown to produce reproductive effects in man and animals. The risks associated with hexachlorobenzene exposure have been determined for a litter using data from a feeding study by Kitchin et al. (1982). The total amount and the concentration of HCB in the litter has been estimated from a pharmacokinetic model. This estimate is consistent with the works of Kitchin et al. (1982), Courtney and Andrews (1985), and others which demonstrate that a large amount of HCB is transferred to the litter, and this quantity increases as a function of the number of lactating days. The transfer of large quantities of HCB caused a significant increase in the number of litters with greater than or equal to 10% mortality when total HCB in the litter was 29-57 mg, equivalent to a concentration of 220-310 micrograms/g. The pharmacokinetic model proved useful in estimating the total effective dose and concentration of HCB in the litter via the dam's experimental dose. The model was also able to calculate the equivalent human exposure, in order to compare it with actual HCB levels from human monitoring data.
已表明六氯苯（HCB）会对人类和动物产生生殖影响。利用Kitchin等人（1982年）喂养研究的数据，确定了一窝动物接触六氯苯的相关风险。通过药代动力学模型估算了一窝动物中六氯苯的总量和浓度。这一估算与Kitchin等人（1982年）、Courtney和Andrews（1985年）以及其他研究结果一致，这些研究表明大量六氯苯会转移到一窝动物中，且该量会随着泌乳天数的增加而增加。当一窝动物中六氯苯总量为29 - 57毫克（相当于浓度为220 - 310微克/克）时，大量六氯苯的转移导致死亡率大于或等于10%的窝数显著增加。药代动力学模型在通过母体的实验剂量估算一窝动物中六氯苯的总有效剂量和浓度方面被证明是有用的。该模型还能够计算等效的人体暴露量，以便与人体监测数据中的实际六氯苯水平进行比较。
