Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Front Cell Infect Microbiol. 2022 Jul 29;12:940532. doi: 10.3389/fcimb.2022.940532. eCollection 2022.
Acute pancreatitis is a common emergent disorder, a significant population of which develops the life-threatening condition, called severe acute pancreatitis (SAP). It is generally accepted that bacterial infection is associated with the development and persistence of SAP. In addition to bacterial infection, recent clinical studies disclosed a high incidence of fungal infection in patients with SAP. Moreover, SAP patients with fungal infection exhibit a higher mortality rate than those without infection. Although these clinical studies support pathogenic roles played by fungal infection in SAP, beneficial effects of prophylactic anti-fungal therapy on SAP have not been proved. Here we summarize recent clinical findings as to the relationship between fungal infection and the development of SAP. In addition, we discuss molecular mechanisms accounting for the development of SAP in the presence of fungal infection.
急性胰腺炎是一种常见的急症，其中一部分患者会发展为危及生命的重症急性胰腺炎（SAP）。一般认为细菌感染与 SAP 的发生和持续存在有关。除细菌感染外，最近的临床研究还揭示了 SAP 患者真菌感染的发生率较高。此外，SAP 合并真菌感染患者的死亡率高于无感染患者。尽管这些临床研究支持真菌感染在 SAP 中的致病作用，但预防性抗真菌治疗对 SAP 的有益作用尚未得到证实。在这里，我们总结了最近关于真菌感染与 SAP 发展之间关系的临床发现。此外，我们还讨论了在真菌感染存在的情况下 SAP 发展的分子机制。
