真菌跨界动态与溃疡性结肠炎对粪便微生物群移植 (FMT) 治疗的反应性相关。
Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis.
机构信息
Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
University of New South Wales, Sydney NSW 2052, Australia; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Concord Repatriation General Hospital, Sydney, NSW 2139, Australia.
出版信息
Cell Host Microbe. 2020 May 13;27(5):823-829.e3. doi: 10.1016/j.chom.2020.03.006. Epub 2020 Apr 15.
Fecal microbiota transplantation (FMT) targeting gut microbiota has recently been successfully applied to ulcerative colitis. However, only a subset of patients responds to FMT, and there is a pressing need for biomarkers of responsiveness. Fungi (the mycobiota) represent a highly immunologically reactive component of the gut microbiota. We analyzed samples from a large randomized controlled trial of FMT for ulcerative colitis (UC). High Candida abundance pre-FMT was associated with a clinical response, whereas decreased Candida abundance post-FMT was indicative of ameliorated disease severity. High pre-FMT Candida was associated with increased bacterial diversity post-FMT, and the presence of genera was linked to FMT responsiveness. Although we detected elevated anti-Candida antibodies in placebo recipients, this increase was abrogated in FMT recipients. Our data suggest that FMT might reduce Candida to contain pro-inflammatory immunity during intestinal disease and highlight the utility of mycobiota-focused approaches to identify FMT responders prior to therapy initiation.
粪便微生物群移植（FMT）针对肠道微生物群，最近已成功应用于溃疡性结肠炎。然而，只有一部分患者对 FMT 有反应，因此迫切需要反应性生物标志物。真菌（真菌群）是肠道微生物群中具有高度免疫反应性的组成部分。我们分析了来自溃疡性结肠炎（UC）FMT 的大型随机对照试验的样本。FMT 前高假丝酵母菌丰度与临床反应相关，而 FMT 后假丝酵母菌丰度降低则表明疾病严重程度得到改善。FMT 前高假丝酵母菌与 FMT 后细菌多样性增加相关，并且某些属的存在与 FMT 反应性相关。尽管我们在安慰剂组中检测到了升高的抗假丝酵母菌抗体，但在 FMT 组中这种增加被消除了。我们的数据表明，FMT 可能会降低假丝酵母菌以控制肠道疾病中的促炎免疫，并强调了专注于真菌群的方法在治疗前识别 FMT 反应者的实用性。
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