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细菌感染和抗生素在帕金森病中的作用的研究进展。

Insights into the roles of bacterial infection and antibiotics in Parkinson's disease.

机构信息

Key Laboratory of Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi, China.

Joint International Research Laboratory of Ethnomedicine of the Ministry of Education, Zunyi Medical University, Zunyi, China.

出版信息

Front Cell Infect Microbiol. 2022 Jul 28;12:939085. doi: 10.3389/fcimb.2022.939085. eCollection 2022.

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which is accompanied with the classical motor symptoms and a range of non-motor symptoms. Bacterial infection affects the neuroinflammation associated with the pathology of PD and various antibiotics have also been confirmed to play an important role not only in bacterial infection, but also in the PD progression. This mini-review summarized the role of common bacterial infection in PD and introduced several antibiotics that had anti-PD effects.

摘要

帕金森病(PD)是最常见的神经退行性疾病之一,其伴有典型的运动症状和一系列非运动症状。细菌感染会影响与 PD 病理相关的神经炎症,并且各种抗生素不仅在细菌感染中,而且在 PD 进展中也被证实发挥着重要作用。本综述总结了常见细菌感染在 PD 中的作用,并介绍了几种具有抗 PD 作用的抗生素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a32/9366083/73de7390f3c5/fcimb-12-939085-g001.jpg

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