• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

腮腺及下颌下唾液腺原发性无色素性恶性黑色素瘤：1例罕见病例报告

Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report.

作者信息

Sultana Mehebuba, Chatterjee Rudra Prasad, Kundu Sanchita, Mahmud Sk Abdul

机构信息

Department of Oral and Maxillofacial Pathology, GuruNanak Institute Of Dental Science And Research, Kolkata, West Bengal, India.

出版信息

J Oral Maxillofac Pathol. 2022 Apr-Jun;26(2):263-267. doi: 10.4103/jomfp.jomfp_183_21. Epub 2022 Jun 28.

DOI:10.4103/jomfp.jomfp_183_21
PMID:35968175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364651/
Abstract

Primary amelanotic malignant melanomas (AMMs) of the parotid and submandibular salivary glands are extremely rare with only a few reported cases due to its low incidence and misdiagnosis. Malignant melanoma (MM) has a high predilection for the head-and-neck region and majority of the cases in the parotid gland reported as association with metastasis in and around the gland from a cutaneous primary tumor. Immunohistochemistry is solely needed for confirmation of diagnosis and MMs give positive reactivity for melan-A, HMB-45, and S-100. Prognosis for AMM in the mucosal or salivary gland regions is much poorer than cutaneous regions because of anatomic considerations and its delayed diagnosis. The treatment of choice is radical surgery and parotidectomy along with radiotherapy and chemotherapy.

摘要

腮腺和颌下唾液腺的原发性无色素性恶性黑色素瘤极为罕见，因其发病率低且易误诊，仅有少数病例报道。恶性黑色素瘤（MM）高度好发于头颈部区域，腮腺中大多数病例报告为与皮肤原发性肿瘤转移至腮腺及其周围有关。确诊仅需免疫组织化学检查，MM对黑素A、HMB-45和S-100呈阳性反应。由于解剖学因素及诊断延迟，黏膜或唾液腺区域的无色素性恶性黑色素瘤的预后比皮肤区域差得多。首选治疗方法是根治性手术及腮腺切除术，同时辅以放疗和化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/02339409cc87/JOMFP-26-263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/81454acc1742/JOMFP-26-263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/5fba1eaa8220/JOMFP-26-263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/34ed0c52d62a/JOMFP-26-263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/e3af0907f3e3/JOMFP-26-263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/02339409cc87/JOMFP-26-263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/81454acc1742/JOMFP-26-263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/5fba1eaa8220/JOMFP-26-263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/34ed0c52d62a/JOMFP-26-263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/e3af0907f3e3/JOMFP-26-263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dba/9364651/02339409cc87/JOMFP-26-263-g005.jpg

相似文献

1
Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report.腮腺及下颌下唾液腺原发性无色素性恶性黑色素瘤：1例罕见病例报告
J Oral Maxillofac Pathol. 2022 Apr-Jun;26(2):263-267. doi: 10.4103/jomfp.jomfp_183_21. Epub 2022 Jun 28.
2
A rare case of amelanotic malignant melanoma in the oral region: Clinical investigation and immunohistochemical study.口腔区域无色素性恶性黑色素瘤1例罕见病例：临床研究与免疫组织化学分析
Oncol Lett. 2015 Dec;10(6):3761-3764. doi: 10.3892/ol.2015.3819. Epub 2015 Oct 20.
3
Oral amelanotic melanoma.口腔无色素性黑色素瘤。
Ann Ib Postgrad Med. 2012 Jun;10(1):6-8.
4
[Primary malignant melanoma of the parotid gland: a case report and review of the literature].[腮腺原发性恶性黑色素瘤：一例报告并文献复习]
HNO. 2008 Jun;56(6):627-32. doi: 10.1007/s00106-007-1634-5.
5
HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas.对于原发性口腔和鼻腔黏膜黑色素瘤的免疫组织化学诊断，HMB-45可能是比S-100或Melan-A更敏感的标志物。
J Oral Pathol Med. 2005 Oct;34(9):540-5. doi: 10.1111/j.1600-0714.2005.00340.x.
6
Parotid gland malignant melanomas.腮腺恶性黑色素瘤
Arch Pathol Lab Med. 2000 Dec;124(12):1780-4. doi: 10.5858/2000-124-1780-PGMM.
7
Primary non-cutaneous melanomas of the head and neck: Case series and review of the literature.头颈部原发性非皮肤黑色素瘤：病例系列及文献综述
SAGE Open Med Case Rep. 2024 Jun 20;12:2050313X241262155. doi: 10.1177/2050313X241262155. eCollection 2024.
8
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader.头皮无色素性黑色素瘤的腮腺转移：极具伪装性的疾病。
Head Neck. 2016 Apr;38(4):E91-4. doi: 10.1002/hed.24222. Epub 2015 Sep 8.
9
Primary Squamous Cell Carcinoma of Submandibular Salivary Gland with Sialo-Cutaneous Fistula: A Rare Case Report.伴有涎皮瘘的下颌下唾液腺原发性鳞状细胞癌：1例罕见病例报告
J Clin Diagn Res. 2015 Aug;9(8):PD03-5. doi: 10.7860/JCDR/2015/14017.6409. Epub 2015 Aug 1.
10
Primary amelanotic malignant melanoma of the parotid gland: a case report.腮腺原发性无色素性恶性黑色素瘤：一例报告
J Int Med Res. 2008 Nov-Dec;36(6):1435-9. doi: 10.1177/147323000803600633.

引用本文的文献

1
Primary non-cutaneous melanomas of the head and neck: Case series and review of the literature.头颈部原发性非皮肤黑色素瘤：病例系列及文献综述
SAGE Open Med Case Rep. 2024 Jun 20;12:2050313X241262155. doi: 10.1177/2050313X241262155. eCollection 2024.

本文引用的文献

1
Oral malignant melanoma: An aggressive clinical entity - Report of a rare case with review of literature.口腔恶性黑色素瘤：一种侵袭性临床实体——1例罕见病例报告并文献复习
J Int Soc Prev Community Dent. 2016 Mar-Apr;6(2):176-81. doi: 10.4103/2231-0762.175145.
2
Oral malignant melanoma: A case report of an unusual clinical and histologic presentation.口腔恶性黑色素瘤：一例具有不寻常临床和组织学表现的病例报告。
Dent Res J (Isfahan). 2013 May;10(3):404-7.
3
Primary oral malignant melanoma: two case reports and review of literature.原发性口腔恶性黑色素瘤：两例病例报告及文献综述
Case Rep Dent. 2012;2012:975358. doi: 10.1155/2012/975358. Epub 2012 Jul 30.
4
Primary amelanotic malignant melanoma of the parotid gland: a case report.腮腺原发性无色素性恶性黑色素瘤：一例报告
J Int Med Res. 2008 Nov-Dec;36(6):1435-9. doi: 10.1177/147323000803600633.
5
Immunophenotyping of amelanotic melanoma. A case report.无色素性黑色素瘤的免疫表型分析。病例报告。
Acta Dermatovenerol Alp Pannonica Adriat. 2006 Sep;15(3):141-3.
6
Primary malignant melanomas of the parotid gland.
Oral Surg Oral Med Oral Pathol. 1961 Jan;14:108-16. doi: 10.1016/0030-4220(61)90479-0.
7
Primary mucosal malignant melanoma of the head and neck.头颈部原发性黏膜恶性黑色素瘤
Head Neck. 2002 Mar;24(3):247-57. doi: 10.1002/hed.10019.
8
Amelanotic melanoma: the great masquerader.无色素性黑色素瘤：强大的伪装者。
J Am Acad Dermatol. 2000 May;42(5 Pt 1):731-4. doi: 10.1067/mjd.2000.103981.
9
Malignant melanomas of the parotid: comparison of survival for patients with metastases from known vs unknown primary tumor sites.
Arch Otolaryngol Head Neck Surg. 1999 Jun;125(6):635-9. doi: 10.1001/archotol.125.6.635.
10
Primary malignant melanoma in the oral mucosal membrane with metastasis in the cervical lymph node: MR appearance.口腔黏膜原发性恶性黑色素瘤伴颈部淋巴结转移：磁共振成像表现
AJNR Am J Neuroradiol. 1998 May;19(5):954-5.