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Phase separation may drive mitochondrial nucleoid compartmentation.

作者信息

Dalamaga Maria, Liu Junli

机构信息

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias, Goudi, 11527, Athens, Greece.

Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Diabetes Institute, Shanghai, China.

出版信息

Metabol Open. 2022 Aug 5;15:100205. doi: 10.1016/j.metop.2022.100205. eCollection 2022 Sep.

DOI:10.1016/j.metop.2022.100205
PMID:35968262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9372768/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a948/9372768/3cb5285437d4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a948/9372768/3cb5285437d4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a948/9372768/3cb5285437d4/gr1.jpg

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Metabol Open. 2022 Aug 5;15:100205. doi: 10.1016/j.metop.2022.100205. eCollection 2022 Sep.
2
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本文引用的文献

1
Ectopic biomolecular phase transitions: fusion proteins in cancer pathologies.异位生物分子相变：癌症病理学中的融合蛋白。
Trends Cell Biol. 2022 Aug;32(8):681-695. doi: 10.1016/j.tcb.2022.03.005. Epub 2022 Apr 25.
2
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation.相分离驱动线粒体拟核的自组装以进行转录调控。
Nat Struct Mol Biol. 2021 Nov;28(11):900-908. doi: 10.1038/s41594-021-00671-w. Epub 2021 Oct 28.
3
Paraspeckle nuclear condensates: Global sensors of cell stress?核内包涵体：细胞应激的全局感受器？
Bioessays. 2021 May;43(5):e2000245. doi: 10.1002/bies.202000245. Epub 2021 Mar 22.
4
Self-assembly of multi-component mitochondrial nucleoids via phase separation.通过相分离实现多组分线粒体核小体的自组装。
EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23.
5
Biomolecular Condensates in the Nucleus.核内生物分子凝聚物。
Trends Biochem Sci. 2020 Nov;45(11):961-977. doi: 10.1016/j.tibs.2020.06.007. Epub 2020 Jul 17.
6
Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation.细菌 RNA 聚合酶簇是通过液-液相分离组装而成的生物分子凝聚物。
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18540-18549. doi: 10.1073/pnas.2005019117. Epub 2020 Jul 16.
7
Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19.述评：磷酸二酯酶 4 抑制剂作为针对 COVID-19 细胞因子风暴的潜在辅助治疗靶点。
Metabolism. 2020 Aug;109:154282. doi: 10.1016/j.metabol.2020.154282. Epub 2020 Jun 1.
8
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences.评估活细胞中的相分离：诊断、注意事项和功能后果。
Genes Dev. 2019 Dec 1;33(23-24):1619-1634. doi: 10.1101/gad.331520.119. Epub 2019 Oct 8.
9
RNA polymerase II clustering through carboxy-terminal domain phase separation.RNA 聚合酶 II 通过羧基末端结构域相分离聚集。
Nat Struct Mol Biol. 2018 Sep;25(9):833-840. doi: 10.1038/s41594-018-0112-y. Epub 2018 Aug 20.
10
Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.RNA 聚合酶 II C 端高度磷酸化的相分离机制。
Nature. 2018 Jun;558(7709):318-323. doi: 10.1038/s41586-018-0174-3. Epub 2018 May 30.