Kano Y, Grosovsky A J, Little J B
Int J Cancer. 1987 Jul 15;40(1):64-8. doi: 10.1002/ijc.2910400112.
The changes in the frequencies of X-ray-induced mutations to 6-thioguanine resistance, chromosomal abnormalities and transformation to anchorage-independent growth were examined during confluent holding recovery in density-inhibited cultures of human diploid fibroblasts. Chromosomal abnormalities studied included non-stable aberrations, deletions, and reciprocal translocations measured up to 20 mean population doublings post-irradiation. Complex recovery kinetics were observed. A comparison of these kinetics suggests that reciprocal translocations are associated with the induction of both transformation and mutations. Mutagenesis correlated with deletions and translocations, whereas transformation correlated with translocations only.
在人二倍体成纤维细胞的密度抑制培养物汇合维持恢复期间，检测了X射线诱导的对6-硫代鸟嘌呤抗性的突变频率、染色体异常以及向不依赖贴壁生长转化的变化。所研究的染色体异常包括不稳定畸变、缺失以及在照射后多达20个平均群体倍增时测量的相互易位。观察到了复杂的恢复动力学。对这些动力学的比较表明，相互易位与转化和突变的诱导均相关。诱变与缺失和易位相关，而转化仅与易位相关。
