Bianchi R, Romani L, Puccetti P, Fioretti M C
Int J Cancer. 1987 Jul 15;40(1):7-11. doi: 10.1002/ijc.2910400103.
Lymphocytes immune to a highly immunogenic ("xenogenized") variant of a murine lymphoma--which were shown to exert anti-xenogenized tumor activity in a previously described model of tumor immunotherapy--were tested in the present study for possible suppressive effects on the growth of an i.c. graft of the original lymphoma. Remarkable tumor-inhibitory effects followed the i.v. infusion of splenic lymphocytes sensitized or restimulated in vitro, or derived from animals immunized in vivo with the xenogenized tumor cells. The pattern of inhibition of the parental cells was apparently similar to that previously described for the xenogenized variant, but preliminary evidence suggests that the underlying mechanisms may be different.
对一种鼠淋巴瘤的高免疫原性（“异种源化”）变体具有免疫性的淋巴细胞——在先前描述的肿瘤免疫治疗模型中已显示出对异种源化肿瘤具有抗瘤活性——在本研究中测试其对原位移植的原始淋巴瘤生长可能的抑制作用。静脉输注在体外致敏或再刺激的脾淋巴细胞，或来自动物体内用异种源化肿瘤细胞免疫的脾淋巴细胞后，出现了显著的肿瘤抑制作用。亲代细胞的抑制模式显然与先前描述的异种源化变体相似，但初步证据表明其潜在机制可能不同。
