Veng-Pedersen P, Miller R
Int J Clin Pharmacol Ther Toxicol. 1987 May;25(5):233-7.
A method is presented which enables the rate and extent of gastrointestinal release to be evaluated at steady state. The method requires a solution of the drug to be given orally as a reference in the same subject receiving the test product. The special mathematical and numerical aspect of the method is discussed. The method which makes use of the previously published deconvolution computer program DCON is demonstrated by evaluating the gastrointestinal release of a theophylline sustained release product at steady state.
本文介绍了一种能够在稳态下评估胃肠道释放速率和程度的方法。该方法要求在接受测试产品的同一受试者中口服药物溶液作为参比。讨论了该方法特殊的数学和数值方面。通过评估稳态下茶碱缓释产品的胃肠道释放，证明了利用先前发表的去卷积计算机程序DCON的方法。
