Geisler Daniel, Almutairi Fawaz, John Ivy, Quiroga-Garza Gabriela, Yu Michelle, Seethala Raja, Bastacky Sheldon
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Urol Case Rep. 2022 Jul 31;45:102176. doi: 10.1016/j.eucr.2022.102176. eCollection 2022 Nov.
Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity.
球旁细胞瘤（JGCTs）是一种罕见的、通常为良性的肿瘤；只有极少数病例在临床或组织学上为恶性。我们在此报告一例23岁男性患者的恶性JGCT病例，该病例临床未被怀疑，诊断具有挑战性，报告其组织学、免疫表型和分子特征。通过电子显微镜确诊。该病例以其显著的有丝分裂活性（此前JGCTs中未见报道）以及GATA3免疫组化阳性这一新发现而引人注目。
