Onder Sevgen, Baydar Dilek Ertoy
Department of Pathology, Hacettepe University Hospital, Ankara, Turkey.
Int J Surg Pathol. 2011 Feb;19(1):65-70. doi: 10.1177/1066896909333416. Epub 2009 Apr 29.
Juxtaglomerular cell tumors constitute a very small group among the renal neoplasms. Most secrete renin, causing hypertension and hypokalemia due to secondary hyperaldosteronism. They have characteristic pathological features. For the accurate evaluation, diagnosis has to be confirmed by immunohistochemical staining for renin or electron microscopic demonstration of renin protogranules. This report presents a case of renal juxtaglomerular cell tumor in a 63-year-old man with previously unreported histological findings in addition to classic morphology.
肾小球旁细胞瘤在肾肿瘤中占比极小。多数此类肿瘤分泌肾素,因继发性醛固酮增多症导致高血压和低钾血症。它们具有特征性病理表现。为进行准确评估,必须通过肾素免疫组化染色或肾素原颗粒的电镜显示来确诊。本报告介绍了一例63岁男性的肾肾小球旁细胞瘤,除经典形态外,还有此前未报告的组织学表现。