Balázs M
Int J Dermatol. 1987 May;26(4):227-30. doi: 10.1111/j.1365-4362.1987.tb00905.x.
The morphologic examination of neonatal subcutaneous fat necrosis is reported. Subcutaneous nodules after prolonged labor and asphyxia appeared in the skin of the back and neck. Biopsy was performed at 16 days. The infants' general state did not change and the nodules spontaneously regressed. Light microscopically focal necroses of the subcutaneous adipose tissue were present, with granulation tissue. Electron microscopy revealed complex material replacing the necrotic fat cells. Two types of crystals could be observed: short, rectangular ones irregularly arranged and long, needle-shaped ones, parallel or radial in arrangement. The dissolved lipid crystals were surrounded by membranes that probably arose from the necrotic fat cells. The crystals passed the cytoplasm membrane of the macrophages. Giant cells arose from macrophages, partly by fusion of the cells and partly by amitosis.
报道了新生儿皮下脂肪坏死的形态学检查。长时间分娩和窒息后，背部和颈部皮肤出现皮下结节。在第16天进行了活检。婴儿的一般状况未改变，结节自行消退。光镜下可见皮下脂肪组织局灶性坏死，并伴有肉芽组织。电镜显示有复杂物质取代坏死的脂肪细胞。可观察到两种类型的晶体：短的、矩形的，排列不规则；长的、针状的，平行或呈放射状排列。溶解的脂质晶体被可能源自坏死脂肪细胞的膜所包围。晶体穿过巨噬细胞的细胞质膜。巨细胞部分由细胞融合、部分由无丝分裂从巨噬细胞产生。
