Friedman S J, Winkelmann R K
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Cutan Pathol. 1989 Apr;16(2):99-105. doi: 10.1111/j.1600-0560.1989.tb00018.x.
Multiple subcutaneous plaques and nodules appeared on the back and the dorsal proximal area of the extremities of a 9-day-old male infant after a complicated prenatal period necessitating cesarean section. The clinical and histological features were diagnostic of subcutaneous fat necrosis of the newborn. Light microscopy revealed adipocyte necrosis, a lymphohistiocytic infiltrate, and needle-shaped clefts within adipocytes and macrophages. Ultrastructurally, there were aggregations of electron-lucent spaces in the form of spindles and needles arranged in parallel within the altered adipocytes; macrophages surrounded these cells or their fragments and invaded the fat lobules. Enzyme histochemical staining, not previously reported in the literature, showed that acid phosphatase, leucine aminopeptidase, and indoxyl and non-specific esterases were present in the areas of fat necrosis.
一名9天大的男婴在经历了需要剖宫产的复杂孕期后，其背部和四肢近端背侧出现了多个皮下斑块和结节。临床和组织学特征诊断为新生儿皮下脂肪坏死。光镜检查显示脂肪细胞坏死、淋巴细胞和组织细胞浸润，以及脂肪细胞和巨噬细胞内的针状裂隙。超微结构上，在改变的脂肪细胞内有呈纺锤体和针状平行排列的电子透亮区聚集；巨噬细胞围绕这些细胞或其碎片并侵入脂肪小叶。酶组织化学染色（此前文献未报道）显示，脂肪坏死区域存在酸性磷酸酶、亮氨酸氨肽酶、吲哚酚和非特异性酯酶。
