Sapkota Rishi R, Tak Raj Kumar, Aryal Vivek, Niroula Doleshwar, Secosky Nicholas C, Dhungana Roshan K, Giri Ramesh
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Org Lett. 2022 Aug 26;24(33):6213-6218. doi: 10.1021/acs.orglett.2c02531. Epub 2022 Aug 15.
We report a Cu(II)-catalyzed cyclization/coupling of alkenyl aldimines with arylzinc reagents to create indole-3-diarylmethane derivatives (Sapkota et al. , DOI: 10.26434/chemrxiv-2022-d6qn). The current reaction provides a unified modular route from readily available starting materials to indole-3-diarylmethanes in which all three arene cores can be decorated with differential functional substitutions on demand. Since the cyclization/coupling of alkenyl aldimines is unknown to date, the current method widens the scope with regard to both the substrate and product diversity for this class of reaction.
