Donati L, Signorini M, Busnach G, Noé L, Mazza E
Int J Tissue React. 1987;9(3):215-8.
The first cause of death in burned patients is still sepsis. A great number of studies point out a serious immunodeficiency due to several circulating mediators. Nowadays early excision and plasma exchange appear to be the most efficient procedures in order to remove from the patient these circulating agents. Therefore in this study the authors have treated 8 patients (average age 25 years), who presented an average of total burned surface of 49%, with plasma exchange performed early after injury. The results of PMN and lymphocyte function tests showed a significant therapeutic correction of these parameters in patients treated with plasma exchange. The clinical observations agreed with the results: in 7 patients with positive outcome, no invasive infections were recorded. The positive results obtained warrant further investigation with this procedure.
烧伤患者的首要死因仍是脓毒症。大量研究指出，由于多种循环介质的存在，患者存在严重的免疫缺陷。如今，早期切除和血浆置换似乎是从患者体内清除这些循环介质最有效的方法。因此，在本研究中，作者对8例患者（平均年龄25岁）进行了治疗，这些患者的平均烧伤总面积为49%，在受伤后早期进行了血浆置换。中性粒细胞和淋巴细胞功能测试结果显示，接受血浆置换治疗的患者这些参数有显著的治疗性改善。临床观察结果与这些结果一致：7例预后良好的患者未记录到侵袭性感染。所获得的阳性结果值得对该方法进行进一步研究。
