Department of Pediatric Neurology, Miyagi Children's Hospital, Sendai, Japan.
Department of Pediatric Neurology, Miyagi Children's Hospital, Sendai, Japan.
Brain Dev. 2022 Nov;44(10):748-752. doi: 10.1016/j.braindev.2022.08.001. Epub 2022 Aug 13.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired demyelinating disease of the peripheral nervous system with unknown etiology. Alopecia universalis, an advanced form of alopecia areata (AA), is a condition characterized by complete hair loss. Here we report the first case of childhood CIDP associated with AA who was successfully treated with a combination of intravenous immunoglobulin (IVIg) and corticosteroids. CASE REPORT: This case describes a nine-year-old Japanese girl who developed alopecia, progressive muscle weakness, and eventually loss of walking ability (at ages 2, 4, and 7, respectively). She was treated with IVIg and prednisolone combination therapy, which improved muscle weakness and alopecia. She was positive for serum IgG-GM2 type anti-glycolipid antibodies, which may be associated with this rare combination of diseases.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种获得性脱髓鞘性周围神经系统疾病，病因不明。广泛性脱发是斑秃（AA）的一种严重形式，其特征是完全脱发。在这里，我们报告首例儿童 CIDP 与 AA 相关的病例，该病例成功接受了静脉注射免疫球蛋白（IVIg）和皮质类固醇的联合治疗。
本病例描述了一名 9 岁日本女孩，她先后出现脱发、进行性肌肉无力，最终丧失行走能力（分别在 2、4 和 7 岁时）。她接受了 IVIg 和泼尼松龙联合治疗，肌肉无力和脱发均有所改善。她的血清 IgG-GM2 型神经节苷脂抗体呈阳性，这可能与这种罕见的疾病组合有关。
