Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 63 ro 10, Yeongdeungpo-gu, Seoul, 07345, Republic of Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2022 Aug 15;12(1):13820. doi: 10.1038/s41598-022-15612-w.
The effects of forced vital capacity (FVC) on clinical outcomes of asthma-chronic obstructive pulmonary diseases overlap (ACO) are still unknown. We conducted this study to examine the association of FVC on clinical outcomes in ACO. Data from the Korean COPD Subgroup Study cohort were analyzed. Patients who fulfilled the ACO criteria were included and grouped according to FVC changes, such as FVC-incline and FVC-decline. No significant differences were observed between the FVC-incline and FVC-decline groups in baseline clinical characteristics. In a year after, FVC-decline group experienced more moderate (47.1% vs. 36.8%, p = 0.02) and moderate-to-severe (49.8% vs. 39.6%, p = 0.03) acute exacerbations (AEs), compared to FVC-incline group. The frequency of moderate AEs (1.3 ± 2.1 vs. 0.9 ± 1.7, p = 0.03) and moderate-to-severe AEs (1.5 ± 2.5 vs. 1.1 ± 1.9, p = 0.04) were higher in the FVC-decline group than in the FVC-incline groups. After adjusting for confounding factors, FVC-decline group was associated with moderate AEs (odds ratio [OR] = 1.58; 95% confidence interval [CI] 1.02-2.44; p = 0.04), and moderate-to-severe AEs (OR = 1.56; 95% CI 1.01-2.41; p < 0.05) in ACO patients, which was not seen in FEV changes. FVC changes are associated with clinical outcomes in ACO.
用力肺活量（FVC）对哮喘-慢性阻塞性肺疾病重叠（ACO）临床结局的影响尚不清楚。我们进行了这项研究，以检查 FVC 与 ACO 临床结局的关系。分析了韩国 COPD 亚组研究队列的数据。符合 ACO 标准的患者被纳入，并根据 FVC 的变化（如 FVC 增加和 FVC 下降）进行分组。在基线临床特征方面，FVC 增加组和 FVC 下降组之间没有显著差异。在一年后，FVC 下降组经历了更多的中度（47.1%比 36.8%，p=0.02）和中重度（49.8%比 39.6%，p=0.03）急性加重（AE），与 FVC 增加组相比。中度 AE 的频率（1.3±2.1 比 0.9±1.7，p=0.03）和中重度 AE 的频率（1.5±2.5 比 1.1±1.9，p=0.04）在 FVC 下降组中均高于 FVC 增加组。在调整混杂因素后，FVC 下降组与中度 AE（比值比 [OR] 1.58；95%置信区间 [CI] 1.02-2.44；p=0.04）和中重度 AE（OR 1.56；95% CI 1.01-2.41；p<0.05）相关，而在 FEV 变化中则没有这种情况。FVC 变化与 ACO 患者的临床结局相关。
