Fujiki Rei, Kawayama Tomotaka, Furukawa Kyoji, Kinoshita Takashi, Matsunaga Kazuko, Hoshino Tomoaki
Fujiki Medical and Surgical Clinic, Miyazaki, 880-2112, Japan.
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, 830-0011, Japan.
J Asthma Allergy. 2022 Oct 26;15:1549-1559. doi: 10.2147/JAA.S381985. eCollection 2022.
Few questionnaires evaluate daytime and nighttime symptoms separately, although these assessments could contribute to the improvement of disease control levels and prevention of future risks in asthma. The purpose of this retrospective study was to investigate whether daytime and nighttime visual analog scales (VAS) are useful in measuring the perception of symptoms, assessing disease control levels, and evaluating the treatment effects in asthma.
Self-reporting asthma control tests (ACT) before and after treatment are standardized tests used to determine disease control levels. A multiple regression analysis was performed to determine the correlation between daytime and nighttime VAS and the characteristics of patients before treatment, as well as the changes in VAS and lung functions and fractional exhaled nitrogen oxide after treatment in 55 treatment-naïve symptomatic adult patients with asthma.
Both daytime ( = -0.57, < 0.0001) and nighttime ( = -0.46, < 0.0001) VAS correlated well with ACT scores, and there was a correlation between daytime and nighttime VAS ( = 0.33, = 0.0148) before treatment. In addition, the changes in daytime ( = -0.65, < 0.0001) and nighttime ( = -0.44, < 0.0001) VAS were significantly associated with changes in the ACT scores. The multiple regression analysis ( [95% confidence interval]) revealed that improvements in the daytime (-2.33 [-4.55 to -0.11], = 0.0405) and nighttime (-3.09 [-6.25 to 0.07], = 0.0505) VAS were associated with an increased forced vital capacity after treatment, although there was no correlation between the VAS and characteristics before treatment.
Our study demonstrated that daytime and nighttime VAS were useful in assessing disease control levels and evaluating the treatment effects in asthma.
尽管对白天和夜间症状进行单独评估有助于改善哮喘疾病控制水平及预防未来风险，但很少有问卷能做到这一点。这项回顾性研究的目的是调查白天和夜间视觉模拟量表（VAS）在测量症状感知、评估疾病控制水平以及评估哮喘治疗效果方面是否有用。
治疗前后的自我报告哮喘控制测试（ACT）是用于确定疾病控制水平的标准化测试。对55例初治有症状的成年哮喘患者进行多元回归分析，以确定白天和夜间VAS与治疗前患者特征之间的相关性，以及治疗后VAS、肺功能和呼出一氧化氮分数的变化。
白天（=-0.57，<0.0001）和夜间（=-0.46，<0.0001）VAS均与ACT评分密切相关，且治疗前白天和夜间VAS之间存在相关性（=0.33，=0.0148）。此外，白天（=-0.65，<0.0001）和夜间（=-0.44，<0.0001）VAS的变化与ACT评分的变化显著相关。多元回归分析（[95%置信区间]）显示，白天（-2.33[-4.55至-0.11]，=0.0405）和夜间（-3.09[-6.25至0.07]，=0.0505）VAS的改善与治疗后用力肺活量增加有关，尽管VAS与治疗前特征之间无相关性。
我们的研究表明，白天和夜间VAS在评估哮喘疾病控制水平和治疗效果方面是有用的。
