Department of Nursing, Chung Shan Medical University Hospital, Taichung, Taiwan.
Department of Nursing, Chung-Shan Medical University, Research Consultant, Chung-Shan Medical University Hospital, Taichung, Taiwan.
Int J Nurs Pract. 2023 Aug;29(4):e13094. doi: 10.1111/ijn.13094. Epub 2022 Aug 15.
The purpose of this study was to examine the efficacy of cryotherapy with frozen gloves for the prevention of the chemotherapy-induced peripheral neuropathy of the hand.
Most breast cancer patients receive chemotherapy; consequently, patients frequently experience adverse effects of chemotherapy-induced peripheral neuropathy.
A quasi-experimental and prospective self-controlled study was conducted. Breast cancer patients wore frozen glove on the dominant hand for 90 min during their weekly treatment with paclitaxel (80 mg/m ). Treatment of the dominant hand, the intervention group, was continued for 12 weeks. The non-dominant hand was considered the control group.
A total of 22 patients participated in this study, and only one patient did not reach the cumulative dose (960 mg/m ). Findings show that the incidences of sensory and motor symptoms of chemotherapy-induced peripheral neuropathies at the following times (Time 1 to Time 4) were significantly lower in the intervention group than in the control group. However, although the incidences of motor symptoms were lower in the experimental group than in the control group, a significant difference was shown only at Time 4. Additionally, both groups of patients reported that their incidence of sensory symptoms were higher than those of motor symptoms.
Cryotherapy with frozen gloves is useful in reducing both the sensory and motor symptoms of the chemotherapy-induced peripheral neuropathy of the hands.
本研究旨在探讨冷冻手套冷冻疗法对手部化疗引起的周围神经病变的预防效果。
大多数乳腺癌患者接受化疗；因此，患者经常经历化疗引起的周围神经病变的不良反应。
采用准实验前瞻性自身对照研究。在每周紫杉醇（80mg/m ）治疗期间，乳腺癌患者将冷冻手套戴在优势手上 90 分钟。治疗优势手，即干预组，持续 12 周。非优势手为对照组。
共有 22 名患者参与了这项研究，只有 1 名患者未达到累积剂量（960mg/m ）。结果表明，干预组在以下时间（时间 1 到时间 4）的化疗引起的周围神经病变的感觉和运动症状的发生率明显低于对照组。然而，尽管实验组的运动症状发生率低于对照组，但仅在时间 4 时显示出显著差异。此外，两组患者均报告感觉症状的发生率高于运动症状。
冷冻手套冷冻疗法有助于减少手部化疗引起的周围神经病变的感觉和运动症状。
