Hossain Md Fahad, Kharel Manish, Rajib Mostafa Hasan, Khan Mahfuza A, Anwar Md Yasin, Lamsal Yogesh, Aziz Syed Nurul
Hospital Medicine, Ministry of Health, Upazila Health Complex, Kishoreganj, BGD.
Medicine and Surgery, Jahurul Islam Medical College, Bhagalpur, BGD.
Cureus. 2023 Aug 24;15(8):e44026. doi: 10.7759/cureus.44026. eCollection 2023 Aug.
The chemotherapeutic agent paclitaxel has significantly enhanced the treatment of various types of cancer. However, the quality of life of cancer patients is often impacted by the painful and dose-restrictive paclitaxel side effect known as paclitaxel-induced peripheral neuropathy (PIPN). A non-pharmacological method called cryotherapy has shown promise in alleviating PIPN-related symptoms. In this systematic review, we aimed to evaluate the safety and effectiveness of cryotherapy in preventing PIPN. The review analyzed four randomized controlled trials (RCTs) involving individuals treated with paclitaxel for breast and gynecological cancer. Cryotherapy showed success in lowering PIPN symptoms in several studies, as judged by various outcome measures, although the findings varied. The safety profile of cryotherapy was typically good, with minimal side effects. However, methodological variations and small sample sizes in the studies analyzed limit drawing definitive conclusions from them. To obtain conclusive evidence, studies with standardized techniques and larger sample sizes are required. Further research is necessary to understand cryotherapy's potential mechanisms and long-term effects. This review highlights the potential of cryotherapy in the management of PIPN, explains how it works, and suggests future research topics to improve its application.
化疗药物紫杉醇显著改善了各类癌症的治疗效果。然而，癌症患者的生活质量常常受到紫杉醇引起的外周神经病变（PIPN）这种疼痛且限制剂量的副作用的影响。一种名为冷冻疗法的非药物方法在缓解与PIPN相关的症状方面显示出了前景。在这项系统评价中，我们旨在评估冷冻疗法预防PIPN的安全性和有效性。该评价分析了四项随机对照试验（RCT），这些试验涉及接受紫杉醇治疗的乳腺癌和妇科癌症患者。尽管研究结果各不相同，但根据各种结局指标判断，冷冻疗法在多项研究中成功减轻了PIPN症状。冷冻疗法的安全性通常良好，副作用极小。然而，所分析研究中的方法差异和样本量较小限制了从中得出明确结论。为了获得确凿证据，需要采用标准化技术且样本量更大的研究。有必要进行进一步研究以了解冷冻疗法的潜在机制和长期效果。本评价突出了冷冻疗法在管理PIPN方面的潜力，解释了其作用方式，并提出了未来改善其应用的研究课题。
