Curran W J, Hecht-Leavitt C, Schut L, Zimmerman R A, Nelson D F
Int J Radiat Oncol Biol Phys. 1987 Jul;13(7):1093-8. doi: 10.1016/0360-3016(87)90049-6.
Fifty-six patients who previously received therapeutic cranial irradiation (CRT) were imaged by a 1.5 Magnetic Resonance (MR) System 0.1-11 years following CRT. Abnormal MR findings within the treatment volume unrelated to tumor, prior to surgery, or coexisting conditions were reviewed for an association with CRT. Twenty-four patients had MR abnormalities considered to be attributable to CRT. These were scored as mild (Grade I) in 6, moderate (Grade II) in 9, and severe (Grade III) in 9. Eight of these 24 patients with CRT findings on MR had CT abnormalities that correlated with the MR. Six lesions seen on computed tomography (CT) were Grade III abnormalities; all were judged as being visualized better by MR. Eight patients had significant neurologic dysfunction attributable to their CRT lesions, and 7 of these had Grade III lesions. Whereas the clinical significance of mild or moderate CRT effects seen on MR is uncertain, Grade III (severe) MR lesions correlate well with important clinical findings.
56名先前接受过治疗性颅脑照射（CRT）的患者在CRT后0.1至11年接受了1.5磁共振（MR）系统成像。在手术前或并存疾病之前，对治疗体积内与肿瘤无关的异常MR表现进行了评估，以确定其与CRT的关联。24名患者的MR异常被认为归因于CRT。其中6例评分为轻度（I级），9例为中度（II级），9例为重度（III级）。这24例MR显示有CRT表现的患者中，8例CT异常与MR相关。计算机断层扫描（CT）上发现的6个病变为III级异常；所有这些病变经判断在MR上显示得更好。8例患者因CRT病变出现明显神经功能障碍，其中7例有III级病变。虽然在MR上看到的轻度或中度CRT效应的临床意义尚不确定，但III级（重度）MR病变与重要临床发现密切相关。
