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Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer's disease: a meta-analytic review on potential mechanisms.骨髓间充质干细胞移植改善阿尔茨海默病动物模型的认知缺陷并减轻神经病理学:潜在机制的荟萃分析综述。
Transl Neurodegener. 2020 May 27;9(1):20. doi: 10.1186/s40035-020-00199-x.
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A clinicopathological approach to the diagnosis of dementia.以临床病理方法诊断痴呆症。
Nat Rev Neurol. 2017 Aug;13(8):457-476. doi: 10.1038/nrneurol.2017.96. Epub 2017 Jul 14.
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Alzheimer's disease, dementia, and stem cell therapy.阿尔茨海默病、痴呆症与干细胞疗法。
Stem Cell Res Ther. 2017 May 12;8(1):111. doi: 10.1186/s13287-017-0567-5.
9
Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease.给予人类成人缺血耐受间充质干细胞和因子可减轻阿尔茨海默病小鼠模型中的β淀粉样蛋白病变。
Neurobiol Aging. 2017 Mar;51:83-96. doi: 10.1016/j.neurobiolaging.2016.11.009. Epub 2016 Nov 24.
10
Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia.路易体痴呆:路易体痴呆症和帕金森病痴呆症。
Continuum (Minneap Minn). 2016 Apr;22(2 Dementia):435-63. doi: 10.1212/CON.0000000000000309.

干细胞治疗综述:阿尔茨海默病和帕金森病痴呆症的新兴治疗方法。

A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease.

机构信息

Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.

Department of Research and Project, Clinton Global Initiative University, New York, New York.

出版信息

Brain Behav. 2022 Sep;12(9):e2740. doi: 10.1002/brb3.2740. Epub 2022 Aug 15.

DOI:10.1002/brb3.2740
PMID:35971625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9480940/
Abstract

AIM

This article aims to study the benefits and disadvantages of stem cell therapy, especially for patients who have dementia.

METHODS

The databases PubMed, Google Scholar, and the National Library of Medicine were searched for literature. All papers on Alzheimer's disease, Lewy body dementia, Parkinson's disease, stem cell therapy, and its effect on dementia treatment were considered.

RESULTS

Stem cell treatment has demonstrated promising outcomes in animal studies by positively modifying the degenerative alterations in dementia. However, it is not without drawbacks, such as ethical concerns while using embryonic stem cells and the danger of developing cancer if the cells undergo uncontrolled differentiation.

CONCLUSION

Although stem cell therapy has its risks, it has the potential to be a viable therapeutic option for patients with dementia if developed appropriately. Hence, more research and clinical trials are needed to establish its efficacy in this context.

摘要

目的

本文旨在研究干细胞治疗的益处和弊端,特别是针对痴呆症患者。

方法

检索了 PubMed、Google Scholar 和美国国家医学图书馆的数据库,以寻找关于阿尔茨海默病、路易体痴呆、帕金森病、干细胞治疗及其对痴呆症治疗效果的文献。

结果

干细胞治疗在动物研究中通过积极改变痴呆症的退行性改变显示出有前景的结果。然而,它并非没有缺点,例如在使用胚胎干细胞时存在伦理问题,如果细胞不受控制地分化,可能会有致癌的危险。

结论

尽管干细胞治疗存在风险,但如果得到适当开发,它有可能成为痴呆症患者的一种可行的治疗选择。因此,需要更多的研究和临床试验来确定其在这方面的疗效。