Dermatological Students Scientific Association, Department of Dermatology, Venerology and Allergology, Faculty of Medicine, Medical University of Gdansk, 17th Str. Smoluchowskiego, PL-80-214 Gdansk, Poland.
Acta Derm Venereol. 2022 Sep 21;102:adv00777. doi: 10.2340/actadv.v102.2416.
Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T-cell lymphoma. GG homozygote rs8193036 A/G of interleukin-17A gene occurred less commonly in the cutaneous T-cell lymphoma group; however, patients with this single-nucleotide polymorphism experience significantly intense pruritus. Conversely, the rs2397084 AG heterozygote of interleukin-17F is more common in the lymphoma population. In addition, there were significant differences in the frequencies of interleukin-17 genotypes when comparing early (Ia to IIa) and advanced stages (IIb, III and IV) of this neoplasms. A similar result has been shown in comparison between Sézary syndrome and mycosis fungoides. The current data may serve as a possible explanation for the increased bacterial infection rates in the course of cutaneous T-cell lymphoma, especially caused by Staphylococcus aureus. In summary, specific single-nucleotide polymorphisms occur with different frequencies between cutaneous T-cell lymphoma and healthy patients. Moreover, genetic predisposition of several interleukin-17 single-nucleotide polymorphisms may be a factor causing impaired immune defence in cutaneous lymphomas.
肿瘤微环境对皮肤 T 细胞淋巴瘤的进展有重要影响。本研究采用序列特异性引物的聚合酶链反应，分析了 150 例皮肤 T 细胞淋巴瘤患者白细胞介素-17 基因的单核苷酸多态性。白细胞介素-17A 基因 rs8193036 GG 纯合子 A/G 在皮肤 T 细胞淋巴瘤组中较少见；然而，具有这种单核苷酸多态性的患者瘙痒明显剧烈。相反，白细胞介素-17F 的 rs2397084 AG 杂合子在淋巴瘤人群中更为常见。此外，在比较这种肿瘤的早期（Ia 至 IIa）和晚期（IIb、III 和 IV）时，白细胞介素-17 基因型的频率存在显著差异。在比较蕈样肉芽肿和赛泽里综合征时也出现了类似的结果。目前的数据可能为皮肤 T 细胞淋巴瘤过程中细菌感染率增加提供了一种可能的解释，尤其是金黄色葡萄球菌引起的感染。总之，皮肤 T 细胞淋巴瘤和健康患者之间特定的单核苷酸多态性发生频率不同。此外，白细胞介素-17 单核苷酸多态性的遗传易感性可能是导致皮肤淋巴瘤免疫防御受损的一个因素。
