Kitts D D, Anderson G B, Handwerger S, BonDurant R H, Stabenfeldt G H
J Anim Sci. 1987 Jun;64(6):1696-702. doi: 10.2527/jas1987.6461696x.
Simultaneous fetal and maternal ovine placental lactogen (oPL) and prolactin (oPRL) measurements were determined from blood samples collected from six mixed breed (MB; gestation = 141.5 +/- .7 d) pregnancies and single Rambouillet (n = 2; Ra gestation = 148 and 149 d) and Finnish Landrace (n = 2; Finn gestation = 141 and 143 d) pregnancies for the purpose of examining a possible relationship between fetal-maternal oPL and oPRL levels in the prepartal period. The MB pregnancies were produced by embryo transfer and consisted of genetically different fetuses co-existing in a common uterine environment. Despite the apparent prematurity of Ra co-twins in MB pregnancies, similar oPL and oPRL patterns during the final 14 d of gestation were observed for both Ra and Finn co-twins. Fetal oPL levels decreased at parturition (range 23 to 90 ng/ml) to approximately 60% of values recorded 8 d prepartum (range 100 to 150 ng/ml) in both fetal siblings. Increases in fetal oPRL concentrations, first observed at approximately 4 d prepartum in all fetuses, reached peak concentrations (40 to 60 ng/ml) at term. Results of this study suggest a similarity in regulation of fetal oPL and oPRL secretion, despite genetic differences for gestation period, in fetuses in the M.B. pregnancy.
从六只杂种（MB；妊娠期 = 141.5 ± 0.7天）怀孕母羊、两只兰布莱绵羊（n = 2；兰布莱绵羊妊娠期分别为148天和149天）以及两只芬兰长白绵羊（n = 2；芬兰长白绵羊妊娠期分别为141天和143天）采集的血样中，同时测定了胎儿和母体的绵羊胎盘催乳素（oPL）和催乳素（oPRL）水平，目的是研究分娩前期胎儿 - 母体oPL和oPRL水平之间可能存在的关系。MB怀孕母羊是通过胚胎移植产生的，由在共同子宫环境中并存的基因不同的胎儿组成。尽管MB怀孕母羊中的兰布莱绵羊双胎明显早产，但在妊娠最后14天观察到兰布莱绵羊和芬兰长白绵羊双胎的oPL和oPRL模式相似。在分娩时，两个胎儿同胞的胎儿oPL水平均下降（范围为23至90 ng/ml），降至产前8天记录值（范围为100至150 ng/ml）的约60%。所有胎儿在产前约4天首次观察到胎儿oPRL浓度升高，足月时达到峰值浓度（40至60 ng/ml）。本研究结果表明，尽管妊娠期存在基因差异，但MB怀孕母羊中的胎儿在胎儿oPL和oPRL分泌调节方面具有相似性。
