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Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism.五聚体自诱导物-2 外排蛋白的冷冻电镜结构揭示了其运输机制。
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2
A Redox-Based Autoinduction Strategy to Facilitate Expression of 5xCys-Tagged Proteins for Electrobiofabrication.一种基于氧化还原的自诱导策略,用于促进用于电生物制造的5xCys标记蛋白的表达。
Front Microbiol. 2021 Jun 18;12:675729. doi: 10.3389/fmicb.2021.675729. eCollection 2021.
3
Quorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices.群体感应通讯:分子连接细胞、其邻近细胞,甚至是器件。
Annu Rev Chem Biomol Eng. 2020 Jun 7;11:447-468. doi: 10.1146/annurev-chembioeng-101519-124728. Epub 2020 Mar 13.
4
Bacterial co-culture with cell signaling translator and growth controller modules for autonomously regulated culture composition.细菌共培养与细胞信号转导和生长控制器模块,用于自主调节培养组成。
Nat Commun. 2019 Sep 11;10(1):4129. doi: 10.1038/s41467-019-12027-6.
5
Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models.工程益生菌大肠杆菌可消除和预防动物模型中的铜绿假单胞菌肠道感染。
Nat Commun. 2017 Apr 11;8:15028. doi: 10.1038/ncomms15028.
6
Two-Way Chemical Communication between Artificial and Natural Cells.人造细胞与天然细胞之间的双向化学通讯
ACS Cent Sci. 2017 Feb 22;3(2):117-123. doi: 10.1021/acscentsci.6b00330. Epub 2017 Jan 25.
7
Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota.群体感应信号AI-2的调控会影响经抗生素处理的肠道微生物群。
Cell Rep. 2015 Mar 24;10(11):1861-71. doi: 10.1016/j.celrep.2015.02.049.
8
Gene network homology in prokaryotes using a similarity search approach: queries of quorum sensing signal transduction.原核生物中基于相似性搜索方法的基因网络同源性:群体感应信号转导的查询。
PLoS Comput Biol. 2012;8(8):e1002637. doi: 10.1371/journal.pcbi.1002637. Epub 2012 Aug 16.
9
Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'.使用基因编码的 NOR 门和化学“导线”进行稳健的多细胞计算。
Nature. 2011 Jan 13;469(7329):212-5. doi: 10.1038/nature09565. Epub 2010 Dec 8.
10
A synchronized quorum of genetic clocks.一个同步的遗传时钟多数派。
Nature. 2010 Jan 21;463(7279):326-30. doi: 10.1038/nature08753.

群体感应元件开启了新的沟通渠道。

Quorum sensing componentry opens new lines of communication.

机构信息

Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.

Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD, USA.

出版信息

EMBO J. 2022 Sep 15;41(18):e112162. doi: 10.15252/embj.2022112162. Epub 2022 Aug 16.

DOI:10.15252/embj.2022112162
PMID:35971916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9475535/
Abstract

Autoinducer-2 is a key molecule for bacterial quorum sensing. New exporter structures may now help narrow the gap between biology and engineering.

摘要

自体诱导物 2 是细菌群体感应的关键分子。新的外排结构现在可能有助于缩小生物学和工程学之间的差距。