Clifford P S, Bell L B, Hopp F A, Coon R L
J Appl Physiol (1985). 1987 May;62(5):1912-6. doi: 10.1152/jappl.1987.62.5.1912.
The Breuer-Hering reflex (BHR) reappears 12-14 wk after surgical lung denervation in beagle dogs (J. Appl. Physiol. 54: 1451-1456, 1983). To demonstrate that this is due to reinnervation of pulmonary stretch receptors, we recorded nerve activity from regenerated branches of the left vagus nerve in five beagle dogs. Ten days postdenervation the BHR was absent, whereas by 19 mo it was clearly present. Multifiber pulmonary afferent activity was observed in all five dogs with single-fiber activity observed in three. Sectioning the right vagus nerve did not alter the BHR, but sectioning all the regenerated branches of the left vagus abolished the reflex. In two additional dogs studied 17 mo postsurgery, recordings were made from few fiber nerve bundles of the left cervical vagus. Nerve activity was increased during gentle stroking of the surface of the left upper and lower lobes, indicating receptive fields in both lobes. These data demonstrate that reinnervation of pulmonary stretch receptors does occur and provides evidence that reinnervation of these receptors is responsible for return of the BHR after pulmonary denervation.
在比格犬中，布雷尔 - 赫林反射（BHR）在手术切断肺神经支配后12 - 14周重新出现（《应用生理学杂志》54: 1451 - 1456, 1983）。为了证明这是由于肺牵张感受器的重新神经支配，我们记录了5只比格犬左迷走神经再生分支的神经活动。去神经支配后10天，BHR消失，而到19个月时则明显出现。在所有5只犬中均观察到多纤维肺传入活动，其中3只观察到单纤维活动。切断右迷走神经并未改变BHR，但切断左迷走神经的所有再生分支则消除了该反射。在另外2只术后17个月研究的犬中，从左颈迷走神经的少数纤维神经束进行了记录。在轻柔抚摸左肺上叶和下叶表面时，神经活动增强，表明两个肺叶均有感受野。这些数据表明肺牵张感受器确实发生了重新神经支配，并提供了证据证明这些感受器的重新神经支配是肺去神经支配后BHR恢复的原因。
