Rubin S A
J Appl Physiol (1985). 1987 May;62(5):1997-2002. doi: 10.1152/jappl.1987.62.5.1997.
The relationship between two abnormalities of exercise physiology in chronic heart failure patients was investigated: chronotropic incompetence and decrease in core temperature. While at rest, 13 heart failure patients had an average sinus heart rate that was significantly higher than seven normals (92 +/- 13 vs. 82 +/- 10 min-1, P less than 0.05). However, during exercise, the trend of increase in sinus heart rate as a function of work load and O2 uptake was significantly greater in normals compared with heart failure (P less than 0.05), and the absolute increase in heart rate at 50 W of cycle ergometry was larger in normals compared with heart failure (38 +/- 17 vs. 22 +/- 13 min-1, P less than 0.05). Differences in core temperature regulation were also observed. In the normals, core temperature increased from 37.13 +/- 0.33 degrees C at rest to 37.37 +/- 0.31 degrees C at 50 W of exercise (P less than 0.01). In the heart failure patients, core temperature decreased from 36.99 +/- 0.33 degrees C at rest to 36.66 +/- 0.39 degrees C at 50 W of exercise (P less than 0.01). As expected, significant differences in hemodynamic and gas exchange variables were observed between the normals and the heart failure patients both at rest and during exercise. A multiple linear regression analysis was performed of heart rate changes as the dependent variable and thermoregulatory and hemodynamic changes as the independent variables to test for their influence on heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
变时性功能不全和核心体温下降。静息时，13例心力衰竭患者的平均窦性心率显著高于7例正常人（92±13次/分钟对82±10次/分钟，P<0.05）。然而，运动期间，与心力衰竭患者相比，正常人窦性心率随工作负荷和摄氧量增加的趋势显著更大（P<0.05），并且在50W自行车测力计运动时正常人的心率绝对增加幅度大于心力衰竭患者（38±17次/分钟对22±13次/分钟，P<0.05）。还观察到核心体温调节的差异。在正常人中，核心体温从静息时的37.13±0.33℃升至50W运动时的37.37±0.31℃（P<0.01）。在心力衰竭患者中，核心体温从静息时的36.99±0.33℃降至50W运动时的36.66±0.39℃（P<0.01）。正如预期的那样，在静息和运动时，正常人与心力衰竭患者在血流动力学和气体交换变量方面均存在显著差异。以心率变化作为因变量，以体温调节和血流动力学变化作为自变量进行多元线性回归分析，以测试它们对心率的影响。（摘要截断于250字）
