College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, P. R. China.
Chem Asian J. 2022 Oct 4;17(19):e202200698. doi: 10.1002/asia.202200698. Epub 2022 Aug 16.
An efficient selective monoethynylation of 2-oxoacetamides using calcium carbide as a concise solid alkyne source is described. A series of multifunctional compounds, 2-hydroxybut-3-ynamides, are synthesized by this strategy. The salient features of this protocol are the use of inexpensive and easy-to-handle solid alkyne source as a surrogate of inflammable and explosive gaseous acetylene, transition-metal-free and mild condition, wide scope of substrates, high selectivity, high yield, and simple work-up procedure.
本文描述了一种使用碳化钙作为简洁的固体炔源高效选择性单炔基化 2-氧代乙酰胺的方法。该策略合成了一系列多功能化合物 2-羟基丁-3-炔酰胺。该方案的突出特点是使用廉价且易于处理的固体炔源替代易燃和易爆的气态乙炔、无过渡金属且条件温和、底物适用范围广、选择性高、收率高以及后处理操作简单。
