研究砖厂工人职业压力与尿中氧化应激生物标志物（8-羟基脱氧鸟苷和双吡咯）水平之间的关联。
Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers.
作者信息
Mourad Basma Hussein, Gaballah Inas Fawzy
机构信息
From the Occupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
J Occup Environ Med. 2023 Jan 1;65(1):60-66. doi: 10.1097/JOM.0000000000002677. Epub 2022 Aug 16.
OBJECTIVES
The aims of the study are to measure the prevalence and level of occupational stress (OS) and to explore its association with oxidative stress among some brickfield workers.
METHODS
Eighty-six brickfield workers and 90 administrative controls were assessed using the Arabic validated version of the Occupational Stress Index. The urinary levels of oxidative biomarkers; 8-hydroxy-2'-deoxyguanosine and biopyrrins were also measured.
RESULTS
The prevalence of moderate and severe OS in addition to the urinary levels of both oxidative biomarkers was significantly higher among the brickfield workers compared with their controls. Both biomarkers levels were significantly and positively correlated with scores of Occupational Stress Index, duration of employment, and with each other. The receiver operating characteristic analysis showed significant specificity and sensitivity of both biomarkers for determining the level of OS.
CONCLUSIONS
A significant association between occupational and oxidative stresses was detected in brickfield workers.
目的
本研究的目的是测量职业压力（OS）的患病率和水平，并探讨其与一些砖厂工人氧化应激的关联。
方法
使用阿拉伯语验证版职业压力指数对86名砖厂工人和90名行政对照组人员进行评估。还测量了氧化生物标志物的尿水平；8-羟基-2'-脱氧鸟苷和双吡咯。
结果
与对照组相比，砖厂工人中中度和重度职业压力的患病率以及两种氧化生物标志物的尿水平显著更高。两种生物标志物水平均与职业压力指数得分、就业持续时间以及彼此之间呈显著正相关。受试者工作特征分析显示两种生物标志物在确定职业压力水平方面具有显著的特异性和敏感性。
结论
在砖厂工人中检测到职业压力与氧化应激之间存在显著关联。
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