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T-偶数噬菌体的裂解基因t：关于大肠杆菌素和噬菌体基因有共同祖先的证据。

Lysis gene t of T-even bacteriophages: evidence that colicins and bacteriophage genes have common ancestors.

作者信息

Riede I

出版信息

J Bacteriol. 1987 Jul;169(7):2956-61. doi: 10.1128/jb.169.7.2956-2961.1987.

DOI:10.1128/jb.169.7.2956-2961.1987
PMID:3597316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC212333/
Abstract

The lysis gene t of the T-even-like bacteriophage K3 has been cloned and sequenced. The gene codes for a protein with a predicted molecular weight of 25,200. Expression of the complete lysis protein was impossible, but peptides complementing T4 amber mutants in t are described. No known lysis protein of other phages is homologous to protein T. Also, the Escherichia coli phospholipase A is different from protein T. CelB, the lysis protein of the colicin E2 operon, shows a similarity to protein T. Sequences of colicins A, E1, and E2 are related to gene 38 sequences, the gene preceding t and coding for the phage adhesin. A common origin for colicin genes and phage genes is discussed, and a protein region in colicins that is responsible for receptor recognition is predicted.

摘要

类T偶数噬菌体K3的裂解基因t已被克隆和测序。该基因编码一种预测分子量为25200的蛋白质。完整裂解蛋白的表达是不可能的，但描述了能互补T4在t位点的琥珀突变体的肽段。其他噬菌体的已知裂解蛋白与蛋白T没有同源性。此外，大肠杆菌磷脂酶A与蛋白T不同。大肠杆菌素E2操纵子的裂解蛋白CelB与蛋白T有相似性。大肠杆菌素A、E1和E2的序列与基因38序列相关，基因38位于t之前，编码噬菌体粘附素。讨论了大肠杆菌素基因和噬菌体基因的共同起源，并预测了大肠杆菌素中负责受体识别的蛋白质区域。

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J Bacteriol. 1987 Jul;169(7):2956-61. doi: 10.1128/jb.169.7.2956-2961.1987.
2
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本文引用的文献

1
Assignment of the functional loci in the colicin E1 molecule by characterization of its proteolytic fragments.通过对大肠杆菌素E1分子蛋白水解片段的表征确定其功能位点
J Biol Chem. 1982 Jun 10;257(11):6446-51.
2
Nucleotide sequence of the structural gene for colicin E1 and predicted structure of the protein.大肠杆菌素E1结构基因的核苷酸序列及蛋白质的预测结构
Proc Natl Acad Sci U S A. 1982 May;79(9):2827-31. doi: 10.1073/pnas.79.9.2827.
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Establishing homologies in protein sequences.确定蛋白质序列中的同源性。
J Bacteriol. 1999 Jul;181(14):4391-6. doi: 10.1128/JB.181.14.4391-4396.1999.
4
The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective.噬菌体T4 r基因在溶菌抑制和精细结构遗传学中的作用：一个新视角。
Genetics. 1998 Apr;148(4):1539-50. doi: 10.1093/genetics/148.4.1539.
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The missing link in phage lysis of gram-positive bacteria: gene 14 of Bacillus subtilis phage phi 29 encodes the functional homolog of lambda S protein.革兰氏阳性菌噬菌体裂解中的缺失环节：枯草芽孢杆菌噬菌体 phi 29 的基因 14 编码 λ S 蛋白的功能同源物。
J Bacteriol. 1993 Feb;175(4):1038-42. doi: 10.1128/jb.175.4.1038-1042.1993.
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Nucleotide sequence of gene t (lysis gene) of the E. coli phage T4.大肠杆菌噬菌体T4的基因t（裂解基因）的核苷酸序列。
Nucleic Acids Res. 1987 Aug 25;15(16):6736. doi: 10.1093/nar/15.16.6736.
7
Regulation of two nested proteins from gene 49 (recombination endonuclease VII) and of a lambda RexA-like protein of bacteriophage T4.来自基因49（重组内切核酸酶VII）的两种嵌套蛋白以及噬菌体T4的一种类λ RexA蛋白的调控。
Genetics. 1988 Oct;120(2):329-43. doi: 10.1093/genetics/120.2.329.
8
Cloning and DNA sequence of plasmid determinant iss, coding for increased serum survival and surface exclusion, which has homology with lambda DNA.编码增强血清存活能力和表面排斥功能且与λDNA具有同源性的质粒决定因子iss的克隆及DNA序列分析
Mol Gen Genet. 1989 Apr;216(2-3):287-92. doi: 10.1007/BF00334367.
9
Lysis protein T of bacteriophage T4.噬菌体T4的裂解蛋白T
Mol Gen Genet. 1992 Nov;235(2-3):253-8. doi: 10.1007/BF00279368.
10
Bacteriophage lysis: mechanism and regulation.噬菌体裂解：机制与调控。
Microbiol Rev. 1992 Sep;56(3):430-81. doi: 10.1128/mr.56.3.430-481.1992.
Methods Enzymol. 1983;91:524-45. doi: 10.1016/s0076-6879(83)91049-2.
4
Release of colicin E2 from Escherichia coli.大肠杆菌中大肠杆菌素E2的释放
J Bacteriol. 1981 Jul;147(1):186-92. doi: 10.1128/jb.147.1.186-192.1981.
5
A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
6
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Mol Gen Genet. 1981;184(1):111-4. doi: 10.1007/BF00271205.
7
Molecular cloning of the T4 genome: organization and expression of the tail fiber gene cluster 34--38.T4噬菌体基因组的分子克隆：尾丝基因簇34 - 38的组织与表达
Mol Gen Genet. 1981;182(3):445-55. doi: 10.1007/BF00293934.
8
Assignment of the functional loci in colicin E2 and E3 molecules by the characterization of their proteolytic fragments.通过对其蛋白水解片段的表征确定大肠杆菌素E2和E3分子中的功能位点
Biochemistry. 1980 Feb 19;19(4):652-9. doi: 10.1021/bi00545a008.
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Microbiol Sci. 1984 Oct;1(7):168-75.
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Colicin E2 release: lysis, leakage or secretion? Possible role of a phospholipase.大肠杆菌素E2的释放：裂解、渗漏还是分泌？磷脂酶的可能作用。
EMBO J. 1984 Oct;3(10):2393-7. doi: 10.1002/j.1460-2075.1984.tb02145.x.