Dong Qiang, Li Jun, Liu Liu, Aisa Haji Akber, Yili Abulimiti
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.
Phytochemistry. 2022 Nov;203:113351. doi: 10.1016/j.phytochem.2022.113351. Epub 2022 Aug 13.
Five previously undescribed steroidal glycoalkaloids(SGAs)and a rare ring B-seco isosteroidal alkaloid, were isolated from Fritillaria pallidiflora Schrenk, along with six known alkaloids. The structures of these alkaloids were established by comprehensive analyses of the 1D, 2D-NMR and HR-ESI-MS data. Configurations of sugar moieties were resolved by chemical derivations. The isolated compounds showed nitric oxide (NO) inhibitory activities in lipopolysaccharide (LPS) induced RAW264.7 cells, and yibeinone exhibited the strongest inhibitory effects among them. This study revealed that the alkaloids from F. pallidiflora might have significant anti-inflammatory potentials.
从伊犁贝母（Fritillaria pallidiflora Schrenk）中分离出5种此前未被描述的甾体糖苷生物碱（SGA）和1种罕见的B环裂甾体生物碱，以及6种已知生物碱。通过对一维、二维核磁共振和高分辨电喷雾电离质谱数据的综合分析确定了这些生物碱的结构。通过化学衍生法解析了糖部分的构型。分离得到的化合物在脂多糖（LPS）诱导的RAW264.7细胞中表现出一氧化氮（NO）抑制活性，其中异贝母酮的抑制作用最强。本研究表明，伊犁贝母中的生物碱可能具有显著的抗炎潜力。
