从伊犁贝母鳞茎中提取的具有气管舒张作用的新型异甾体生物碱。
New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.
作者信息
Li Yan, Yili Abulimiti, Li Jun, Muhamat Aziz, Aisa Haji Akber
机构信息
Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, PR China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, PR China.
出版信息
Bioorg Med Chem Lett. 2016 Apr 15;26(8):1983-7. doi: 10.1016/j.bmcl.2016.03.001. Epub 2016 Mar 2.
Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3β-d-glucoside (5), imperialine (6), imperialine β-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA2 values of 6.19 ± 0.02 and 8.41 ± 0.10, and EC50 values of 0.65 ± 0.02 μmol L(-1) and 4.40 ± 0.90 nmol L(-1), respectively.
从伊犁贝母鳞茎中分离得到4个新的异甾体生物碱，即伊贝母碱A-D（1-4），以及4个已知生物碱，即西贝母碱-3β-D-葡萄糖苷（5）、西贝母碱（6）、西贝母碱β-N-氧化物（7）和东贝母碱（8）。通过广泛的光谱分析或与文献数据（已知化合物）比较确定了它们的结构。化合物2、3、4和6对离体气管标本呈现明显的浓度依赖性舒张作用，其中化合物3和6表现出显著作用，其pA2值分别为6.19±0.02和8.41±0.10，EC50值分别为0.65±0.02 μmol L(-1)和4.40±0.90 nmol L(-1)。
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